我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

大鼠脾脏收缩功能与α肾上腺素受体亚型的调节(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1999年第2期
页码:
95-96,99
栏目:
论著
出版日期:
1999-03-01

文章信息/Info

Title:
Relationship between α-adrenoceptor subtypes and contraction of rat spleen
作者:
保庭毅1　何泽生1　吴金生1　臧益民2　牛国保2
1第四军医大学唐都医院普通外科　西安 710038　2第四军医大学生理学教研室
Author(s):
Bao Tingyi1;  He Zesheng1; Wu Jinsheng1; Zang Yimin2; NiuGuobao2
1Department of General Surgery, Tandu Hospital, 2Department of Physiology, Fourth Military Medical University, Xi′an 710038
关键词:
受体;  肾上腺素能;  亚型　脾脏　大鼠
Keywords:
receptors;  adrenergic;  subtype　　spleen　　rat
分类号:
-
DOI:
-
文献标识码:
-
摘要:
目的:探讨脾脏收缩功能与α肾上腺素受体(α-AR)及亚型分布的关系。方法:采用药物受体分析方法,测定应用拮抗剂前后,pA2, pD2, EC50,Rmax的值。结果:①对Rmax的抑制:硝苯吡啶(Nif)+育亨宾(Yoh,43% )>哌唑嗪(Praz,39%)>酚妥拉明(Phen,27%)>Yoh(19% );②脾脏NE累积浓度收缩曲线右移程度(在EC50水平),Praz=Nif+Yoh(3.4倍)>Phen(3.0倍)>Yoh(117倍);③各组均能显著降低pD2;④pA2:Praz,Phen,Yoh三者间无差异,但它们均显著高于Nif+Yoh组。结论:①大鼠脾脏α受体亚型为α1,α2,且α1略多于α2亚型。②大鼠脾脏α1受体亚型介导收缩效应并不依赖于细胞外Ca2+的存在。可能α1亚型为α1亚型。
Abstract:
Aim: To investigate the relationship between α-adrenoceptor subtypes and contraction of rat spleen.Methods:A ccording to the effect after agonist or antagonist on NE dose response of preparations, the pA2, pD2, EC50 and Rmax were calculated by using pharmacological methods.Results: ①The suppression of Rmax;Mif+ Yoh(43% )>Praz(39%)>Phen(27%)>Yoh(19%);②NE dose response curves were shifted to the right (at EC50 level)Praz=Nif+Yoh(3.4 fold)>Phen(3.0 fold)>Yoh(1.7 fold) ; ③The pD2 were reduced by each groups; ④Praz≈Phen≈Yoh(P>0.05) but they were higher than Nif+ Yoh group.Conclusion: In spleen of rat, ①the distribulion of α-AR subtypes were both α1type and α2 type,α1>α2, ②The contractile responses induced by α1 subtypes were not depended on intracellular Ca2+. The α1 subtypes were α1B subtypes probably.

参考文献/References

［1］徐端正, 赵定义.药理—受体参数pD2, pA2, pD1′估计—附统一计算机程序.上海第一医学院学报, 1985; 12 (5) : 342.

［2］韩启德.肾上腺素受体研究进展(综述).生理科学进展, 1995;26 (2) : 103.

［3］Han C, Abel PW , Minneman KP.α1-adaenoceptor subtypes linked to different mechanisms for increasing intracellular Ca2+in smooth muscle.Nature, 1987; 329: 333 (6137) 333.

［4］Minneman KP, Han C, Abel PW.Comparison of α1-adrenergic receptor subtypes distinguished by chlorethylclonidine and WB 4101.Mol Pharmacol, 1988; 33 (5) : 509.

[5]Han C,Abel PW ,Minneman KP.Heterogeneity of α1-adrenergic receptors revealed by chlorethylclonidine.Mol Pharmacol, 1987;32 (4) : 505.

备注/Memo

备注/Memo:
(收稿1999-01-20)
更新日期/Last Update: 1999-03-01