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载脂蛋白E基因多态性与心血管疾病的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1999年第2期
页码:
109-110
栏目:
综述
出版日期:
1999-03-01

文章信息/Info

Title:
-
作者:
陈定章
第四军医大学西京医院超声科　西安 710032
Author(s):
-
关键词:
载脂蛋白E　心血管疾病　等位基因
Keywords:
-
分类号:
-
DOI:
-
文献标识码:
-
摘要:
载脂蛋白E(APOE)是一种多态性蛋白, 在脂类的运行和代谢过程中起着十分重要的作用。APOE 基因多态性与高脂血症脂质代谢关系密切, E2等位基因是Ⅲ型高脂蛋白血症的必要条件, E3等位基因在正常人分布频率较高, E4等位基因与高脂血症及冠心病发生率相关, 也是早老性痴呆的一个相关基因。
Abstract:
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参考文献/References

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[3]Utermann G, Pruin N , Steinmetz A , et al.Polymorphism of apolipoprotein E Ⅲ effect of a single polymorphic gene locus on plasman lipid levels in man.Clin genet, 1979; 15 (1) : 63.

[4]Marie LB,Wishmas DL , Stanley E, et al.Apolipoprotein E synthesis in human kidney adrenal gland and liver.Proc Natl Acad Sci USA , 1983; 80: 283.

[5]Newman TC,Dawson PA , Rude LL , et al.Quantitation of apoliporotein E mRNA in the liver and periphoral tissues of nonhuman primates.J Biol Chem , 1985; 260: 2452.

[6]Weisgraber KH, Innerarity TL ,Mahley RW.Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteinue-arginine intercharge at a single site.J Biol Chem ,1992; 257: 2518.

[7]Utermann G, Vogelberg KH.Steinmetz A , et al.Polymorphism of apolipoprotein E Ⅱ Genetics of hyper-lipoproteinemia type Ⅲ . Clin Genet, 1979; 15 (1) : 37262.

[8]Chung BH, Segrest JP.Resistance of a very low density lipoprotein subpopulation from family dysbetali-poprotein to in vitro lipolitic conversion to the low density lipoprotein fraction. J Lipid Res, 1983; 24: 1148.

[9]Eichner JE, Kuller LH, Qrchard TJ , et al.Relation of apolipopretein E phenotype to myocardial infarction and mortality from coronary artery disease,Am J Gardiol, 1993; 71 (2) : 160.

[10]吕礼应, 黄光文, 杨九华.血脂、脂蛋白、载脂蛋白及脂质过氧化物与冠心病.J Clin Cardiol (China) , 1997; 13 (1) : 46.

[11]Utermann G, Hardewg A , Zimmer F, et al. Apolipoprotein E phenotype in patients with myocardial infarction.Hum Genet,1984; 65 (3) : 237.

[12]Cumming AM , Robertson FW.Polymorphism at the apoE locus in relation to risk of co ronary heart disease.Clin Genet, 1984; 25(4) : 310.

[13]Hixson JE.Apolipoprotein E polymorphisms affect atherosclerosis in young males pathobiological dete rminants of atherosclerosis in youth research.Arterioscler Thromb. 1991; 11 (5) : 1237.

[14]Corder EH, Saunders AM , Strttmctter WJ , et al.Gene dose of apolipoprotein E type 4 allele and the risk of A lzheimer′s disease in late oneset families.Science, 1993; 261: 921.

[15]Poirier J , Davigonon J , Bonthillier D, et al.Apolipoprotein E polymorphism and Alzheimer′s disease.Lancet, 1993; 342(8873) : 697.

备注/Memo

备注/Memo:
(收稿1998-10-25　修回1999-02-05)
更新日期/Last Update: 1999-03-01