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|本期目录/Table of Contents|

外周内源性阿片肽对心血管功能的调节(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1999年第2期
页码:
106-108,110
栏目:
综述
出版日期:
1999-03-01

文章信息/Info

Title:
-
作者:
吕顺艳1 综述　朱妙章1　臧益民1　陈绍洋12 审校
第四军医大学　1生理学教研室　2西京医院麻醉科　西安 710032
Author(s):
-
关键词:
内源性阿片肽　心血管调节　外周作用　机制
Keywords:
-
分类号:
-
DOI:
-
文献标识码:
-
摘要:
内源性阿片肽(Endogenous Opioid Peptide, EOP) 是心血管系统重要的调节肽。近年来发现心脏及血管壁均有EOP及其受体的分布, 提示EOP对心血管活动的调节除中枢机制外亦存在外周机制。在缺血等应激状态下, EOP大量释放, 激动心脏阿片受体, 可产生负性肌力作用和诱发心律失常, 参与缺血性心脏病的发生和发展。血 管壁的EOP通过突触前和突触后机制, 降低血管收缩机能, 参与血压调节。阿片受体激活后的细胞内信号转导过程, 涉及腺苷酸环化酶-cAMP系统及Ca2+ , IP3, PLC等第二信使。
Abstract:
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参考文献/References

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备注/Memo

备注/Memo:
(收稿1998-09-09　修回1998-12-14)
更新日期/Last Update: 1999-03-01