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乙醇对心脏乙酰胆硷激活的钾通道的作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第1期
页码:
1-3
栏目:
论著
出版日期:
2000-01-25

文章信息/Info

Title:
The effects of ethanol on acetylcholine activated potassium current of the heart
作者:
藏伟进1;  于晓江1;  藏益民2;  商立军2
1.西安医科大学心血管生理药理研究室，陕西西安 710061；2.第四军医大学生理学教研室
Author(s):
ZANG Wei-jin1;  YU Xiao-jiang 1;  ZANG Yi-min 2;  SHANG Li-jun 2
1Division of Cardiovascular Physiology and Pharmacology, Xi′an Medical University, Xi′an 710061, China; 2 Department of Physiology, Fourth Military Medical University
关键词:
醇;  乙;  心脏;  离子通道;  乙酰胆硷
Keywords:
alcohol;  ethyl;  heart;  ion channels;  acetylcholine
分类号:
Q25
DOI:
-
文献标识码:
A
摘要:
乙醇是心脏抑制剂 ,有明显的降低心肌收缩的作用。神经递质乙酰胆硷 (ACh)调节心脏功能的最重要的离子通道是经鸟苷酸调节蛋白 (G蛋白 )的 βγ亚单位而激活的毒蕈碱型钾通道 (IK,ACh)。作者采用全细胞膜片钳的方法观察了豚鼠心房肌细胞乙酰胆硷激活的钾通道及乙醇对其影响。乙醇对 IK,ACh的抑制呈剂量依赖性效应 ,灌注之后可使 ACh激活的 IK,ACh速率减慢 ,峰值下降。乙醇可抑制 IK,ACh,从而影响副交感神经对心脏的调节作用。
Abstract:
Ethanol is a cardiac depress and it can inhibit the contraction of cardiac muscles. Acetylcholine (ACh) released from parasympathetic nerves binds to muscarinic (M 2) ACh receptor (mAChR) in the heart and this leads to the activation of muscarinic K + channel via the βγ subunit of a G protein. The muscarinic K + channel (I K,ACh ) in guinea pig atrial cells and the effect of an alcohol (ethanol) on I K,ACh were investigated using the whole cell patch clamp technique. Ethanol depressed I K,A ACh in a dosedependent manner and ethanol slowed activation of IK,ACh and reduced peak IK,ACh. The decrease of IK,ACh by ethanol may impair parasympathetic control of the heart.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：1999-08-16.基金项目：为国家自拣科学基盘(Nn 39870334)、国家教委留学回国人员启动基金及世川医学奖学金同学台科研启动基金(No 025)资助
更新日期/Last Update: 2000-01-25