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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2000年第1期

页码:

7-9

栏目:

论著

出版日期:

2000-01-25

文章信息/Info

Title:

Experimental study of the effect of sodium malate on mitochondrial enzymes in myocardial stunning

作者:

高群¹; 　贾国良²;  王立军³;  李兰荪²;  李红梅¹;  叶季鲜¹

1 解放军323医院心肾科, 陕西 西安 710054；2 西京医院心内科； 3南京军区总院心内科

Author(s):

GAO Qun ¹;  JIA Guo-liang ²;  WANG Li-jun ³;  LI Lan-sun ²;  LI Hong-mei ¹;  YE Ji-xian ¹

1Department of Cardiology, No.323th Hospital, Xi′an 710054, Shaanxi, China; 2Department of Cardiology, Xijing Hospital; 3Department of Cardiology, Nanjing Military Command General Hospital

关键词:

晕厥心肌;  线粒体酶;  苹果酸钠

Keywords:

myocardial stunning;  mitochondrial enzyme;  sodium malate

分类号:

Q55

DOI:

-

文献标识码:

A

摘要:

研究晕厥心肌线粒体琥珀酸脱氢酶(SDH)、细胞色素氧化酶(CCO)活性变化及苹果酸钠对其活性的影响。采用在体动物(家兔)晕厥心肌模型,测定心肌ATP含量及线粒体内SDH,CCO活性变化,观察苹果酸钠对上述指标的作用。结果:晕厥心肌线粒体重要酶SHD,CCO的活性降低,苹果酸钠能促进其活性恢复,增加ATP合成。结论:补充重要中间代谢产物对晕厥心肌线粒体功能恢复具有重要意义。

Abstract:

An experiment was conducted to study the activity changes of the succiodehydrogenase (SDH) and cyotochrome oxidase (CCO) in mitochondria and the effect of sodium malate on them in myocardial stunning. The model of myocardial stunning in the animal body (rabbit) was used to detect the ATP production of myocardial and the activity changes of SDH and CCO in mitochondria and to observe the effect of sodium malate on them. It was found that the activities of important enzymes (SDH,CCO) in mitochondria decreased in myocardial stunning, and sodium malate could enhance their reactivity and increase ATP produltion. Complementing the important intermediate substance might be very important to reviving the function of mitochondria in myocardial stunning.

参考文献/References

[1] Braunwaldl E,Klone RA. The stanned myocardium proloned postischemic venticular dysfunction[J]. Circulation, 1982, 66(6): 1146.

[2]Edoute Y,Kotze JCN,Lochner A. Normothermic ischemic corrdiac arrest of the isolated working rat heart[J]. Circ Res,1983,53:663.

[3]Flameng W,Andres J,Ferdinande P. Mitochondrial function in myocardial stunning[J]. J Mol Cell Cardiol,1991,23:1.

[4]John H,et al. Myocardial presservation during is chemia and reperfusion[J]. Am Heart J,1988,115:1094.

[5]郭志凌,赵月华. 局部心肌缺血/再灌注损伤的防治[J]. 心血管病学进展,1993,14(2):95.

[6]窦淑筠. 正常与缺血时心肌线粒体代谢状况[J]. 生理科学进展, 1982,13(2):108.

备注/Memo

备注/Memo:

收稿日期：1998-08-21.

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更新日期/Last Update: 2000-01-25