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硫酸镁拮抗内皮素-1所致大鼠心率失常(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第2期
页码:
81-83
栏目:
论著
出版日期:
2000-03-25

文章信息/Info

Title:
Antagonistic effect of magnesium sulphate on ET-1-induced arrhythmias in rats
作者:
褚晓凌1;  宋莲枝2;  林丽1;  肖向红1;  王超美2;  衷国全2;  袁文俊1
1第二军医大学生理学教研室, 上海200433; 2 上海市职工医学院生理学教研室
Author(s):
CHU Xiao-ling 1;  SONG Lian-zhi 2;  LIN Li 1;  XIAO Xiang-hong 1;  WANG Chao-mei 2;  ZHONG Guo-quan 2;  YUAN Wen-jun 1
1Departmen t of Physiology, Second Military Medical University, Shanghai 200433, China 2Departmen t of Physiology, Shanghai Staff Medical College, Shanghai, China
关键词:
心率失常;  内皮素-1; 硫酸镁; 大鼠
Keywords:
arrhythmia;  endothelin 1;  magnesium suplhate;  rat
分类号:
R541.7; R972.2
DOI:
-
文献标识码:
A
摘要:
目的 观察冠状动脉口旁注射硫酸镁预处理对内皮素 - 1(ET- 1)所致心律失常的作用。方法 在雄性 SD大鼠冠状动脉口近旁注射内皮素 - 1引起室性早搏、室性心动过速、心室纤维性颤动、房室传导阻滞等严重心律失常 ,观察冠状动脉口近旁注射不同剂量的硫酸镁预处理对 ET- 1所致心律失常发生率的影响。结果 硫酸镁 (45 m g/kg)组较 ET- 1对照组心律失常发生率和大鼠死亡率明显降低 (P<0 .0 5 ,P<0 .0 1) ;硫酸镁 (90 m g/kg)组 ,严重心律失常未发生 ,动物无死亡。结论 硫酸镁有拮抗 ET- 1所致心律失常的作用。
Abstract:
In order to study the mechanism of exogenous endothelin to induce arrhythmias,magnesium sulphate was injected close to coronary ostia before ET-1 administration and its effects on ET-1 induced severe arrhythmias were observed,which included premature ventricular contraction,ventricular tachycardia,ventricular fibrillation and atrio ventricular block. The results showed that magnesium sulphate dose dependently reduced ET-1 induced arrhythmias. It indicated that magnesium could intervene the pathway of ET-1 to induce arrhythmias.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：1999-03-26.基金项目：全军“九五”医学科研基金! ( No.96M072 )
更新日期/Last Update: 2000-03-25