我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

川芎汤与冠心Ⅱ号吸收入人血清中阿魏酸的血药浓度-时间曲线(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第4期
页码:
253-254
栏目:
论著
出版日期:
2000-08-01

文章信息/Info

Title:
Comparison of ferulic acid concentration-time profiles absorbed into serum between oral ligusticum wallichi and coronary heart NoⅡdecoctions
作者:
任平1;  黄熙1;  陈可冀2;  张莉1;  王骊丽1;  马晓昌2　
1. 第四军医大学西京医院, 陕西西安710032; 2. 中国中医研究院西苑医院
Author(s):
REN Ping1;  HUANG Xi1;  CHEN Ke-ji2;  JIA Guo-liang1;  GUO Wen-yi1;  MA Xiao-chang2
1.Xijing Hospital, Fourth Military Medical University, Xi′an Shaanxi 710032, China; 2.Xiyuan Hospital, China Academy of Chinese Medicine, Beijing 100091
关键词:
方剂; 血药浓度; 药物配伍禁忌; 川芎; 阿魏酸
Keywords:
chinese medicine formula; concentration-time profiles; drug incompatibility; ligustium chuanxiong; ferulic acid
分类号:
R285.5
DOI:
-
文献标识码:
A
摘要:
目的 探讨方剂配伍对吸收入体内血药浓度及其药物动力学参数的影响。方法 用已建立的HPLC法［1］，测定健康自愿者一次口服川芎汤（1 g*kg-1)、 冠心Ⅱ号汤（6 g/kg，其中川芎为1 g/kg）后血清中阿魏酸（FA）的血药浓度-时间曲线。结果 均表现为双峰现象；川芎汤和冠心Ⅱ号在健康人血清中FA的血药浓度时间曲线下面积（AUC）分别为15735±7064和15886±8062 μg*L-1*min-1；健康人血清中川芎复方来源的FA血药浓度最高和最低定量值之间表现出3～8倍的差异。结论 在冠心Ⅱ号中川芎配伍芍药、红花和丹参等并不影响体内FA的血药浓度及其生物利用度。
Abstract:
AIM To explore the effect of composition of prescription on blood drug concentration in vivo and its pharmacokinetics. METHODS Serum ferulic acid (FA) concentration-time profiles were determined and compared by our previously published method after oral administrations of ligusticum wallichi(1 g/kg) and coronary heart NoⅡdecoctions(6 g/kg)to healthy volunteers. RESULTS There were the two peak phenomenon of serum FA concentration-time curve which was the open one-compartment models. the Area under concentration (AUC) of FA in serum of ligusticum wallichi and coronary heart NoⅡ decoctions in volunteers was 15735±7064 and 15886±8062 μg*L-1*min respectively. there were 3～8 times difference between maximum and minimum quantitative value of serum FA concentration. CONCLUSION In coronary heart NoⅡ decoctions, that ligusticum wallichi add white peony root, safflower and root of red sage don′t affect the blood drug concentration and AUC of FA.

参考文献/References

[1] 黄熙，陈可冀，任平，等. 高效液相色谱直接测定沸水浴处理人血清中冠心Ⅱ号来源的阿魏酸［J］.中国中西医结合杂志， 1999,19(2):71.

［2］ 黄　熙, 陈可冀，任　平， 等. "复方效应成分动力学"新假说:科学证据、要素及意义［J］.中国中药杂志,1997，22(4): 250.

［3］ Huang X，Jiang YP,Wen AD, et al. Is it possible to study the pharmacokinetics of chemical component of decoction? ［J］. CJIM,1995,1(4):297.

［4］黄　熙,夏　天，任　平，等. 川芎伍用丹参煎剂对川芎嗪药物动力学的影响［J］. 中国中西医结合杂志,1994， 14(5): 288.

［5］ 寺泽捷年. 甘草次酸体内代谢研究Ⅱ-大鼠体内代谢［J］. 国外医学中医中药分册,1987,9(2): 31.

备注/Memo

备注/Memo:
收稿日期1999-11-10.
更新日期/Last Update: 2000-08-01