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氯沙坦治疗轻、中度高血压病疗效的评价(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第4期
页码:
257-259
栏目:
论著
出版日期:
2000-08-01

文章信息/Info

Title:
Evaluation of losartan efficacy in patients with mild to moderate essential hypertension
作者:
薛玉生;  郑强荪;  张利华;  杨欣国;  柳荫　
第四军医大学唐都医院心内科, 陕西西安710038
Author(s):
XUE Yu-sheng;  ZHENG Qiang-sun;  ZHANG Li-hua;  YANG Xin-guo;  LIU Yin
Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi'an Shaanxi,710038, China
关键词:
高血压;  血管紧张素II 受体拮抗剂;  氯沙坦;  依那普利
Keywords:
hypertension;  angiotensin II receptor antagonist;  losartan;  enalapril
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的 评价氯沙坦治疗轻、中度高血压病患者的疗效。方法 采用随机双盲试验, 将轻、中度高血压病(EH) 患者随机分为氯沙坦组(36 例) 和依那普利组(34 例) , 分别服用氯沙坦50 mg/d 和依那普利10mg/d, 共8 周。治疗4周后, 对舒张压(DBP) ≥90 mm Hg 的患者, 剂量加倍。于服安慰剂期末和治疗4, 8 周末观察DBP 和收缩压(SBP)及心率(HR)、干咳发生率及临床实验室检查。结果 8 周末, 氯沙坦组有效率为72% , 依那普利组为74% , 两组间无显著差异(P > 0. 05)。两组平均DBP 和SBP 均有显著下降, 两组间血压降幅无显著差异(P > 0. 05)。干咳发生率氯沙坦组(3% ) 明显低于依那普利组(18% , P<0. 01)。结论 氯沙坦50～ 100 mg/d 治疗轻、中度高血压病疗效确切,干咳发生率低。
Abstract:
AIM To evaluate the antihypertensive efficacy and tolerability of the angiotensin II receptor antagonist losartan in patients with mild to moderate essential hypertension. METHODS Patients with mild to moderate hypertension were enrolled in this randomized, double blind study. After 2 weeks placebo baseline phase, patients were randomly allocated to receive losartan 50 mg once daily (losartan group, n=36) or enalapril 10 mg once daily (enalapril group, n=34) for 8 weeks . The daily dosage was doubled in patients whose SiDBP remained≥90 mmHg after 4 weeks treatment. SiDBP, SiSBP, heart rate, the incidence of dry cough and clinical laboratory measurements were assessed at the end of 2 weeks placebo phase, 4 and 8 weeks active treatment. RESULTS At the end of 8 weeks, the effective rates did not differ significantly between the losartan group and the enalapril group (72% vs 74% , P> 0.05). The mean reductions in SiDBP and SiSBP were significant in the two group s, and did not differ significantly between the two groups (P>0.05). The losartan group had a significantly lower rate of dry cough than the enalapril group (3% vs 18% , P < 0. 01). CONCLUSION Losartan 50 ～ 100 mg once daily is effective and well tolerated with a very low incidence of dry cough in patients with mild to moderate hypertension.

参考文献/References

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[3] Roca-Cusachs A, Oigman W , Lepe L, et al. A randomized, double-blind comparison of the antihypertensive efficacy and safety of once-daily losartan compared to twice-daily captopril in mild to moderate essential hypertension[J]. Acta Cardiol,1997, 52 (6) 495.

[4] Dahlof B, Keller SE, Makrisl L, et al. Efficacy and tolerability of losartan potassium and antenolol in patient with mild to moderate essential hypertension[J]. Am J Hypertens, 1995, 8(6): 578.

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备注/Memo

备注/Memo:
收稿日期：2000-03-14.
更新日期/Last Update: 2000-08-01