我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

心肌缺血预适应对单支动脉闭塞性急性心肌梗死患者的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第4期
页码:
273-275
栏目:
论著
出版日期:
2000-08-01

文章信息/Info

Title:
Effect of ischemic preconditioning on the patients with acute myocardial infarction
作者:
张航向;  龚卫琴;  陶凌　
第四军医大学西京医院老年病科, 陕西西安710032
Author(s):
ZHANG Hang-xiang;  GONG Wei-qin;  TAO Lin
Department of Gerontology，Xijing Hospital， Fourth Military Medical University，Xi'an Shaanxi 710032，China
关键词:
心肌梗死; 急性; 心肌缺血预适应; 心肌再灌注; 心肌保护
Keywords:
myocardial infarction;  acute;  ischemic preconditioning;  myocardial reperfusion;  cardioprotection
分类号:
R542.22
DOI:
-
文献标识码:
A
摘要:
目的 观察心肌缺血预适应（IPC）对急性心肌梗死（AMI）患者并发症及预后的影响。方法 对照分析40例无IPC的AMI患者（A组）和50例有IPC的AMI患者(B组)的近期临床资料。结果 B组梗死后泵功能障碍发生率及程度、磷酸肌酸激酶（CPK）峰值、并发症均显著低于A组，近期预后有改善。结论 缺血预适应组CPK的峰值降低，梗死后所致心肌坏死面积减小，从而使泵功能障碍的发生率降低、梗死后室性心律失常、Ⅱ度以上房室传导阻滞及再灌注性心律失常发生率减少。这可能是IPC使AMI患者死亡率降低的主要原因。
Abstract:
AIM The effect of ischemic preconditioning(IPC) on complication and prognosis of the patients with myocardial infarction (AMI) was investigated. METHODS The materials of 40 AMI patients without IPC (group A) and 50 AMI patients with IPC (group B) were analysed. RESULTS Rate and degree of ventricular function failure, peak of CPK and complication in group B were significantly lower than those in group A (P＜0.01), the recently prognosis in group B was improved. CONCLUSIONS Decrease of CPK peak or extent of infarction results in lower rates of pump function failure, decrease of ventricular arrythmia and reperfusion arrythmia in the patients with IPC, it may be the main reason that IPC can reduce mortality of the patients with AMI

参考文献/References

[1] 陶凌，李源，王跃民. 心肌缺血预处理和腺苷预处理对兔心肌缺血保护作用的比较［J］. 心脏杂志， 2000，12(1)：16.

［2］ 牟善初. 心肌缺血预适应［J］. 国外医学*老年医学分册，1996，59（6）：193.

［3］ Solomon B, Henrietta RR, Edward A，et al. The prognostic significance of angina pectoris preceding the occurrence of a first acute myocardial infarction in 4166 consecutive hospitalized patients［J］. Am Heart J, 1992, 123:1481.

［4］ Ovizi M, Klconer RA, Hale SL, et al. Coronary cyclic flow variations "preconditions" ischemic myocardium［J］. Circulation, 1992, 85(2):779.

［5］朱方，马宁，于占久，等. 缺血预处理保护心肌作用的分子生物学机制［J］. 心血管病学进展，1998，19（4）：214.

［6］ Yao Z, Gross GJ. A comparison of adenosine-induced cardioprotection and ischemic preconditioning in dogs. Efficacy, time course, and role of KATP channels［J］. Circulation, 1994, 89(3): 1229.

［7］ Donnelly TJ, Sieves RE, Vissern FL, et al. Heat shock protein induction in rat hearts. A role for improved myocardial salvage after ischemia and reperfusion［J］. Circulation, 1992, 85(2): 769.

　［8］ Kitakaze M, Hori M. Ischemic Preconditioning increases adenosine release and 5'-nucleotidase activity during myocardial ischemia and reperfusion in dogs［J］. Circulation, 1993, 87(1): 208.

［9］ Liu GS, Thornton JD, Van Winkle DM, et al. Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in the rabbit heart［J］. Circulation, 1991, 84(1): 350.

［10］ 高太有，彭侃夫，余洪军，等. 心肌缺血预适应对老年急性心肌梗塞患者近期病死率的影响［J］. 中国老年学杂志，1998，18（4）：205.

备注/Memo

备注/Memo:
收稿日期：1999-11-23.
更新日期/Last Update: 2000-08-01