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|本期目录/Table of Contents|

CGRP在慢性低氧性肺动脉高压大鼠肺中的表达(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第6期
页码:
461-462,465
栏目:
论著
出版日期:
2000-12-01

文章信息/Info

Title:
Expression of CGRP in lung in chronically hypoxic pulmonary hypertensive rats
作者:
陈　胜;  冯华松;  王　琳
第四军医大学唐都医院呼吸内科, 陕西西安710038
Author(s):
CHEN Sheng;  FENG Hua-song; ; WANG Lin
Department of Respiratory Dieases, Tangdu Hospital, Fourth Military Medical University, Xi′an Shaanxi, 710038, China
关键词:
降钙素基因相关肽;  低氧症;  肺动脉高压;  免疫组织化学
Keywords:
calcitonin gene related peptide;  hypoxia pulmonary hypertension;  immunohistochemistry
分类号:
R543.2
DOI:
-
文献标识码:
A
摘要:
本研究观察慢性低氧性肺动脉高压大鼠肺中 CGRP表达的相对含量及其动态变化。应用免疫组织化学 ABC染色法观察大鼠在减压低氧条件下 1周 ,2周 ,4周及正常大鼠肺组织 CGRP的相对含量。结果显示 :低氧使大鼠肺动脉压显著增加 ,且随低氧时间的延长而进一步增高 ,第 1周增加的速率明显加快 ;低氧大鼠肺中 CGRP的表达量明显高于正常对照大鼠 (P<0 .0 1) ,CGRP的表达量依次为低氧 4周 >低氧 1周 >低氧 2周 >正常对照。提示 :CGRP参与慢性低氧性肺动脉高压形成过程中的调节 ;CGRP在慢性低氧中的表达呈阶段性增加 ,可能与低氧早期 CGRP大量释放后造成暂时性耗竭有关。
Abstract:
This study was to observe the contents and their dynamic changes of calcitonin gene related peptide (CGRP) expression of lung in chronically hypoxic hypertensive rats. The contents of CGRP in lung were measured by immunohistochemical ABC staining method after 1,2,4 week hypoxia and in normoxic rats. The results showed that pulmonary artery pressure was significantly increased by hypoxia in rats followed the prolonged time of hypoxia. The contents of CGRP expression in lung in hypoxic rats higher than those in control rats, while 4 weeks of hypoxia > 1 week of hypoxia > 2 week s of hypoxia > normoxi controls in proper order. These findings indicate that CGRP plays an important role in modulating the development of hypoxia-induced pulmonary hypertension. The phase augment of CGRP expression during chronic hypoxia may be related to temporary exhaust after CGRP great release in the early hypoxia.

参考文献/References

[1] Lundberg JM, Franco-cereceda A, Hua X, et al. Co-existence of substance P and calcitonin gene-related peptide-like immunoreactives in sensory nerves in relation to cardiovascular and bronchioconstrictor effect of capsaicin [J]. Eur J Pharmacol, 1985, 108: 315.

[2] Codieux A , Springall DR, Muldery PK, et al. Occurrence, distribution and ontogeny of CGRP immunoreactivity in the rat lower respiratory tract: effect of capsaicin treatment and surgical denervations[J]. Neuroscience, 1986, 19 (2) : 605.

[3] Janssen PL, Tucker A. Calcitonin gene-related peptide modulates pulmonary vascular reactivity in isolated rat lungs [J]. J Appl Physol, 1994, 77 (1) : 142.

[4] Zhao L ,Brown LA ,Qwji AA , et al. A drenomedullin activity in chronically hypoxic rat lungs [J]. Am J Physiol, 1996, 272 ( 2P t2) : H622.

[5] Roncalli M, Springall DR, Maggioni M, et al. Early changes in the calcitonin gene-related peptide (CGRP ) content of pulmonary endocrine cells concomitant with vascular remodeling in the hypoxic rat [J]. Am J Respir Cell Mol Biol, 1993, 9 (5) :467.

备注/Memo

备注/Memo:
收稿日期：1998-06-16.
更新日期/Last Update: 2000-12-01