芪丹通脉片对急性心肌缺血犬血液流变学及生化指标的影响(PDF)
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2001年第2期
- 页码:
- 125-127
- 栏目:
- 论著
- 出版日期:
- 2001-03-01
文章信息/Info
- Title:
- Effect of qidan tongmai tablet on hemorrheology and blood biochemistry in acute experimental myocardial ischemia canine
- Author(s):
- BAO Zhen; XIA Tian; WANG Zong-ren; MA Shi-ping; LONG Yin; LI Jun-chang; MA Jing
- Xiiing Hospita1．Fourth Military Medical University，Xi'an Shaanxi 710032,China
- Keywords:
- qidan tongrnai tablet; myocardial ischemia; hemorrheology; endethclin; creatine kinase; Iactate dehydrogenase
- 分类号:
- R541.4
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的 观察芪丹通脉片对实验性急性心肌缺血状态下犬血液流变学指标、血浆内皮素(ET)、血清肌酸激酶(CK)、乳酸脱氢酶(LDH)的影响。方法 采用结扎冠脉，建成犬心血瘀阻(急性心肌缺血)模型，测定冠脉结扎15min(药前)及药后不同实验时问点全血高切(ηbh)、低切粘度(ηb1)、血浆粘度(ηp)，ET，CK，LDH的含量．结果 与对照组相比，芪丹通脉片显著降低ηbh、ηb1、ηp(P<0．01)，CK，ET，LDH。结论 该药对急性心肌缺血有保护作用．
- Abstract:
- AIM To study the effect of qidan tongrnai tablet on hemorrheology and serum creatine phosphokinase (CK)，lactic dehydrogenase(LDH)and endothelin(ET)in acute myocardial ischemia canine．METHODS The coronary artery ligation was employed to establish the acute myocardial ischemia model with canine as subject.Coronary sinus cannula was inserted through the external jugular vein and qidan tongmai talbet was duodenaHy per[used．Experimental indexes were measured before and after ligation．RESULTS The hemorrheological parameters,including ηbh，ηbl，ηp and serum CK，LDH and ET increased significantly in acute myocardial ischemia canine．In comparison with control，qidan tongmai tablet reduced the increased ηbh，ηbl，ηp obviously (P<0．05～ P<0．01)，it also reduced the CK activity(P<0．05)(P<0．01 vs pretreatment)and LDH as well as ET(P<0．05).CONCLUSION qidan tongmai tablet can lower the blood viscosity,reduce ET and CK in acute myocardia1 ischemia．It is valuable in prevention and treatment of coronary heart disease．
参考文献/References
[1]王宗仁，马世平，陈学福，等．降粘抗栓片对犬血液动力学及血液流变学的影响[J]．微循环杂志，1998，8(2)：35．
[2]陈可冀，史载祥．实用血瘀证学[M]．北京：人民卫生出版社l999，32．
[3]范家骏，赵国欣．血液流变学-基础与临床[M]．西安：陕西科学技术出版社．1995：125-126．
[4]戴穆禾，梁子钧，秦万章，等．黄芪药物对人体红细胞变形能力作用的实验研究[J]．贵州医药，1987,(1):23．
[5]朱伯卿，戴瑞鸿，王受益，等．补气活血药治疗气虚血瘀型心力衰竭的临床观察[J]，中西医结合杂志1987，7(10):591.
[6]张国元,陈思聪，葛蕊华，等.应用免疫抑制法测定CK-同功酶诊断急性心梗[J]．中华内科杂志．1986，25(3)：530-532.
[7]Yanagi SM, Kurilara H，Kimura S,et al.A novel potent vasoconstrictor peptide produced by vascular endothelial cells[J].Nature,1988，322：411.
[8]汤健，唐朝枢，杨军，等．内皮素[M]．北京：北京医科大学中国协和医科大学联音出版社，1994：261-262．
备注/Memo
- 备注/Memo:
- 收稿日期：2000-10-25.基金项目：中国人民解放军新药研究重点项目No．118(1998)
常用功能
统计/Statistics
- 摘要浏览/Viewed919
- 全文下载/Downloads731
- 评论/Comments
更新日期/Last Update: 2001-03-01