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吸烟对大鼠肺动脉压和一氧化氮合酶的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第3期
页码:
183-184
栏目:
论著
出版日期:
2001-05-01

文章信息/Info

Title:
The effect of cigarette smoke on the pulmonary artery pressure and Nitric oxide synthase
作者:
栗　艳;  阎　露
第四军医大学西京医院康复诊疗中心药剂科, 陕西西安710032
Author(s):
LI Yan;  YAN Lu
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an Shaanxi 710032, China
关键词:
吸烟;  肺动脉压;  一氧化氮合酶
Keywords:
cigarette smoke;  pulmonary artery pressure;  nitric oxide synthase
分类号:
R12
DOI:
-
文献标识码:
A
摘要:
目的 探讨长期吸烟对大鼠肺动脉压及一氧化氮合酶的影响。方法 SD雄性大鼠 40只 ,随机分为吸烟组和对照组 ,吸烟组暴露于点燃之烟卷, 每日6 h,于 9个月时检测吸烟组及对照组大鼠的肺动脉平均压 (m PAP)、血清一氧化氮 (NO)、肺动脉结构型一氧化氮合酶 (c NOS)和诱导型一氧化氮合酶 (i NOS)。结果 吸烟组大鼠 m PAP明显高于对照组 ,血清 NO浓度与对照组相比明显减低 ,吸烟组肺细小动脉 c NOS平均吸光度值较对照组明显降低 ,吸烟组大鼠肺细小动脉 i NOS的平均吸光度值较对照组明显增高。结论 烟雾可致肺动脉高压的形成 ,抑制肺细小动脉 cNOS表达、促进肺细小动脉 i NOS表达可能为其重要作用机制之一。
Abstract:
AIM To investigate the effect of cigarette smoke on the pulmonary artery pressure and nitric oxide synthase. METHODS Forty mature male rats were used to study the effect of long time cigarette smoke, the pulmonary artery pressure,NO in serum,cNOS and iNOS were measured in pulmonary artery smooth muscle cell. RESULTS After 9 months exposure,the smoke rats′ mPAP and iNOS increased,while NO in serum and cNOS decreased. CONCLUSION Smoke may be the cause of pulmonary hypertension, depressing the cNOS and increasing the iNOS may be one of the mechanism.

参考文献/References

[1] Steudel W, Scherrer-Crosbie M, Bloch KD, et al. Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3[J]. J Clin Invest, 1998, 101: 2468- 2477.

[2] Giaid A, Saleh D. Reduced expression of endothelial nitric oxide synthase in the lung of patients with pulmonary hypertension [J]. N Engl J Med , 1995, 333: 214- 219.

[3] Smith JD, Mclean SD, Nakayama DK, et al. Nitric oxide causes apoptosis in pulmonary vascular smooth muscle cell [J]. J Surg Res, 1998, 79 (2) : 121- 127.

[4] Mcquillan LP, Leung GK, Marsden PA, et al. Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms[J]. Am J Physiol, 1994, 267: H1921- H1927.

备注/Memo

备注/Memo:
收稿日期：2000-09-16.
更新日期/Last Update: 2001-05-01