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紫外线照射和充氧自血回输对肺心病红细胞膜ATP 酶的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第4期
页码:
260-262
栏目:
论著
出版日期:
2001-07-01

文章信息/Info

Title:
The effects of ultraviolet-radiated and oxygen-charged auto-blood retransfusion treatment on erythrocyte ATPase in cor pulmonale patients
作者:
冯华松1;  张　勇1;  王　琳2
1. 海军总医院呼吸科, 北京100037; 2. 第四军医大学唐都医院呼吸内科, 陕西西安710038
Author(s):
FENG Hua-song ; WANG Lin
Department of Respiratory Diseases, Tangdu Hospital, Fourth Military Medical University, Xi’an Shaanxi, 710038, China
关键词:
肺心病;  输血;  自体;  腺苷三磷酸酶类
Keywords:
pulmonary heart disease;  blood transfusion;  autologous;  adenosine triphosphatases
分类号:
R541. 5
DOI:
-
文献标识码:
A
摘要:
目的观察紫外线照射和充氧自血回输法(自血回输) 对肺心病患者红细胞膜Na.K-ATP 酶(Na 泵) 和Ca.Mg-ATP 酶(Ca 泵) 活性的影响, 探讨该疗法可能的治疗机制。方法 采用生化方法测定30 例肺心病患者治疗前后红细胞膜Na 泵、Ca 泵活性, 并与正常人进行了比较。结果 肺心病患者红细胞膜Na 泵, Ca 泵活性降低; 自血回输后红细胞膜Na 泵、Ca 泵活性增高, 动脉血氧分压(PaO2)、血氧饱和度(SaO2) 和临床状况明显改善。常规治疗组(15例患者) 无变化。结论 红细胞膜ATP 酶活性增高可能为自血回输疗法的治疗机制之一。
Abstract:
AIM To investigate the effects of treatment of ultraviolet-radiated and oxygen-charged auto-blood retransfusion on erythrocyte Na.K-ATPase (Na pump ) and Ca.Mg-ATPase (Ca pump ) activity as to reveal the mechanism of treatment. METHODS Eryth rocyte Na pump and Ca pump activities were measured by biochemistry method before and after treatment of ultraviolet-radiated and oxygen-charged auto-blood retransfusion in 30 cases of cor pulmonale patients. RESULTS Erythrocyte Na pump and Ca pump activities were decreased in corpu lmonale patients and increased after treatment of ultraviolet-radiated and oxygen-charged auto-blood retransfusion as well as partial pressure of oxygen and oxygen saturation in artery blood,and clinical manifestation improved. These changes of routine treatment group (15 patients) had not be found. CONCLUSION The enhencement of eryth rocyte ATPase activity may be one of treatment mechanism of ultraviolet-radiated and oxygen-charged auto-blood retransfusion therapy.

参考文献/References

[1] 彭长福, 杨世民, 张周良, 等. 紫外线照射和充氧自血回输治疗慢性肺心病高粘血症[J]. 第四军医大学学报, 1991, 12(3):174.

[2] 董　伟, 李新建, 陶国枢, 等. 长寿老人红细胞膜ATP 酶及唾液酸的研究[J]. 生物化学和生物物理进展, 1986,3: 49.

[3] 冯华松, 南柏松, 赵连友, 等. 扩张型心肌病与红细胞钠钾钙镁离子及ATP 酶关系的研究[J]. 中华医学杂志, 1992, 72(9):547.

[4] 冯华松, 王　琳, 唐敏章. 老年肺心病红细胞钙泵活性与呼吸衰竭的关系[J]. 中华结核和呼吸杂志, 1995,18(2): 122.

[5] 冯华松, 王　琳, 唐敏章. 24 例老年肺心病红细胞钙-ATP 酶和钙镁含量的变化[J]. 中华老年医学杂志, 1996, 15(3): 140.

[6] 冯华松, 王　琳, 唐敏章. 慢性肺心病呼吸衰竭时红细胞膜钙-ATP 酶活性的观察[J]. 解放军医学杂志, 1996, 21(2): 85.

[7] Kim MS, Akera T. O2 free radicals: cause of ischemia-reperfusion injury to cardiac Na-K-ATPase [J]. Am J Physiol,1987, 252: H252.

备注/Memo

备注/Memo:
收稿日期：2000-09-10.
更新日期/Last Update: 2001-07-01