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高脂饮食兔血管内皮功能障碍的早期变化(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第5期
页码:
352-353,356
栏目:
论著
出版日期:
2001-09-01

文章信息/Info

Title:
Endothelial preserved dysfunction is the early change of vascular endothelial function in hyperlipid diet rabbits
作者:
刘群锋;  马　虹;  周少春;  郑振声
中山医科大学附属第一医院心血管内科, 广东广州510080
Author(s):
LIU Qun-feng ; MA Hong ;  ZHOU Shao-chun;  ZHENG Zhen-sheng
Department of Cardiology, first Affiliated Hospital, Sun Yat-Sen University of Medical Sciences,Guangzhou Guangdong 510080, China
关键词:
内皮;  一氧化氮;  高胆固醇血症
Keywords:
endothelium;  nitric oxide;  hypercholesterolermia
分类号:
R543
DOI:
-
文献标识码:
A
摘要:
目的 探讨高脂饮食兔血管内皮功能的早期变化。方法 20 只高脂饮食兔分别于实验前及实验第1, 2, 3, 4 周随机抽取4 只, 颈内静脉插管, 抽血测血脂、基础一氧化氮(NO ) 水平, 随后颈内静脉内注射1 ml.kg- 1乙酰胆碱(Ach, 100 nmol.L - 1) , 5 m in 后从插管处抽血测Ach 刺激后NO 水平。结果 随着胆固醇的逐渐上升, 基础NO 水平与Ach 刺激后NO 水平均下降, 与实验前比较, 基础NO 水平至实验2 周时才出现差异(P < 0. 05) , 而Ach 刺激后NO 水平在实验1 周时即出现差异(P < 0. 05)。结论 胆固醇水平升高导致血管内皮功能受损, 内皮功能障碍首先表现为内皮储备功能障碍, 接着出现静息时内皮细胞障碍。
Abstract:
AIM To study the early change of vascular endothelial function in hyperlipid diet rabbits . METHODS Four rabbits were randomly selected from 20 rabbits before experiment and 1 week, 2 week, 4 week and 8 week after treatment with high lipid diet. A catheter was inserted into the right jugular vein and the blood samples were drawn inorder to measure serum lopids and NO. NO was also examined 5 minutes after 1 m l.kg- 1 acetylcholine (Ach ) (100 nmol.L- 1) was in travenously injected. RESULTS The NO production was gradually reduced in rabbits treated with hyperchlesterol diet as time passed. Compared with those before experiment, basal NO production had no difference in the first week, and shown to bestatistical difference in the second week (P < 0. 05) ; However, NO production stimulated by Ach was shown to be different in the first week (P < 0. 05). CONCLUSION Hypercholesterolemia results in the endothelial dysfunction. This endothelial disorder is characterized by the impairment in Ach stimulated NO formation firstly with subsequent injured basal NO production, a phenomenon with the early impaired endothelial preserved function.

参考文献/References

[1] Guido A , Beatrice MZ. Non-invasive detection of endothelial dysfunction in the hypercholesterolaemic subjects [J].Atherosclerosis, 1994, 114: 247- 254.

[2] Celemajer DS, Sorensen KE, Gooch RM , et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis[J]. Lancet, 1992, 340: 1111- 1115.

[3] 余艳辉, 瞿湘萍, 李　智, 等. 兔高脂蛋白血症模型建立及动脉粥样斑块形成的方法学[J]. 中国药理学通报, 1998, 14 (5) : 1732.

[4] Barry S, Oemar MD,Marcel R, et al. Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis[J]. Circulation, 1998, 97: 2494.

备注/Memo

备注/Memo:
收稿日期：2000-12-05.
更新日期/Last Update: 2001-09-01