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C 型钠尿肽与高血压及左室肥厚的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第5期
页码:
354-356
栏目:
论著
出版日期:
2001-09-01

文章信息/Info

Title:
Relationship between Type C natriuretic peptide and hypertension and left ventricle hypertrophy
作者:
冯华松1;  张　勇1;  费改顺2;  汪　海2
1. 海军总医院, 北京100037; 2. 军事医学科学院毒物药物研究所, 北京100850
Author(s):
FENG Hua-song1;  ZHANG Yong1;  FEI Gai-shun2; WANG Hai2
1. General Hospital of Navy Army, Beijing 100037, China; 2. Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850, China
关键词:
C 型钠尿肽;  高血压;  心肌肥厚;  自发性高血压大鼠
Keywords:
natriuretic peptide;  Type C;  hypertension;  myocardial hypertrophy;  spontaneously hypertensive rats
分类号:
R544
DOI:
-
文献标识码:
A
摘要:
目的 初步探讨血浆C 型钠尿肽(CNP) 水平与高血压及左室肥厚程度的相关性。方法 采用卒中易感型自发性高血压大鼠(SHRSP) , 并与正常血压大鼠(WKY) 作对照, 应用放射免疫方法检测CNP 水平。结果 SHRSP组收缩压(SBP) 和反映左室肥厚的指标如左心室加室间隔(LV + S) 重量和(LV + S)/体重(BW ) 比值均明显高于WKY组(P < 0. 01) ; SHRSP 血浆CN P 水平(145±42 ng/L ) 明显高于W KY (72±11 ng/L ) , 差异非常显著(P < 0. 01) ;SHRSP 血浆CNP 与SBP, (LV + S)/ BW 均呈正相关(P < 0. 05) , 而CNP 与心率(HR)、右心室(RV ) 重量和BW 则未见明显相关性(P > 0. 05)。结论 血浆CNP 水平可以反映高血压及左室肥厚程度。
Abstract:
AIM To investigate the correlations between plasma Type C natriuretic peptide (CNP)levels and the degree of hypertension and left ventricle hypertrophy in stroke-prone spontaneously hypertensive rats (SHRSP ). METHODS The plasma concent rations of CNP were measured by means of radio immunoassay in SHRSP and compared with those of normotensive rats (Wistar-Kyo to rat,WKY). RESUTLS Systolic blood pressure (SBP) and left ventricle puls septum (LV+ S) weight and (LV + S)/ body weight (BW ) ratio were markedly higher in SHRSP than in WKY( P < 0. 01). Plasma CNP levels were 145±42 ng/L and 72±11 ng/L in SHRSP and in WKY respectively, and the difference were significant (P < 0. 01). There were positive correlations between CNP and SBP as well as CNP and (LV + S)/ BW (P < 0. 05) , while CNP had no significant correlations with heart rate (HR) , right ventricle (RV ) weight and BW (P > 0. 05).CONCLUSION CNP may reflex the degree of hypertension and left ventricle hypertrophy.

参考文献/References

[1] Sodoh T, Minamino N , Kangwaw K, et al. C-type natriuretic peptide (CNP) : A new member of the natriuretic peptide family identified in polcine brain [J]. Biochem Biophys Res Commun,1990, 168 (2) : 863.

[2] Arimura JJ , Minamino N , Kangawa K, et al. Isolation and identification of C-type natriuretic peptide in chicken brain [J].Biochem Biophys Res Commun, 1991, 174 (1) : 142.

[3]Komatau Y, Nakao K, Suga S, et al. C-type natriuretic peptide tissue Distribution and molecular form in rats [J]. Circulation,1991, 84 (4) : 1730.

[4]Stingo AJ , Clavell L ,Aarhus LL , et al.Cardiovascular and renal actions of C-type natriuretic peptide [J]. Am J Physiol, 1992,262 (1 part 2) : H308.

[5]冯华松, 臧益民, 朱妙章, 等. VNP、CNP 和ANP 降低慢性低氧性肺动脉高压作用的对比研究[J]. 中华结核和呼吸杂志, 2000,23 (7) : 427- 428.

备注/Memo

备注/Memo:
收稿日期：2000-04-03.基金项目: 国家1035 工程项目(No. 969010101)
更新日期/Last Update: 2001-09-01