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卡托普利对心力衰竭患者QT 离散度及血浆AngII , TXB2, 6-keto-PGF1α影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第5期
页码:
377-378,380
栏目:
论著
出版日期:
2001-09-01

文章信息/Info

Title:
Effect of captopril on QT dispersion and the plasma levels of AngII ,TXB2, 6-keto-PGF1α concentration in chronic congestive heart failure
作者:
张新霞1;  崔长琮1;  雷仁义2;  张　钲2
1. 西安交通大学第一医院心内科, 陕西西安710061; 2. 兰州医学院第一附属医院心内科, 甘肃兰州730000
Author(s):
ZHANG Xin-xia1;  CUI Chang-cong1; LEI Ren-yi2;  ZHANG Zheng2
1.Department of Cardiology, first teaching hospital of Xi’an Jiaotong University, Xi’an Shaanxi 710061, China; 2. Department of Cardiology, first hospital of Lanzhou Medical College ,Lanzhou Gansu 730000, China
关键词:
心力衰竭;  充血性;  前列腺素;  血栓素A2;  卡托普利; QT 离散度
Keywords:
heart failure;  congestive;  prostaglandin F1α;  throm boxane A2;  captopril; QT dispersion
分类号:
R541.61　
DOI:
-
文献标识码:
A
摘要:
目的 探讨卡托普利治疗慢性充血性心力衰竭(CHF) 对肾素-血管紧张素系统和前列腺素系统及QT 离散度(QTd) 的影响。方法 用放射免疫法测定40 例CHF 患者卡托普利治疗2 周前后血浆AngII , TXB2, 6-keto-PGF1α浓度; 手工测量同步12 导联心电图QTd。结果 ①卡托普利治疗2 周后QTd 无明显变化; ②血浆AngII , TXB2 浓度和TXB2/6-keto-PGF1α比值明显下降; 6-keto-PGF1α水平显著升高; ③血浆TXB2 的降低与6-keto-PGF1α的升高呈负相关( r= - 0. 59, P < 0. 01) ; 平均动脉压的下降与6-keto-PGF1α的升高呈正相关( r= 0. 41, P < 0. 05)。结论 卡托普利2 周治疗有利于恢复心力衰竭患者体液内环境的稳定; 但对QTd 无显著影响。
Abstract:
AIM To study the effects of captopril on QTd and plasm a levels of AngII , TXB2, 6-keto-PGF1α in patients with chronic congestive heart failure (CHF). METHODS Forty patients with CHF treated with captopril were observed. Two weeks later, the QT in terval was measured in synchrony 12 leads ECG, the levels of plasm a AngII , TXB2, 6-keto-PGF1α were measured by radio immunoassay. RESULTS ①The QTd was not significantly decreased after treated with captopril for two weeks. ②The levels of plasm a AngII , TXB2 and the ratio of TXB2/6-keto-PGF1α were significantly decreased, while the levels of plasma 6-keto-PGF1α were significantly increased (P < 0. 01, respectively). ③The decrease of TXB2 was inversely related to the increase of 6-keto-PGF1α( r= - 0. 59, P < 0. 01) ; and that of mean artery pressure was positively related to the increase of 6-keto-PGF1α( r= 0. 41, P < 0. 05). CONCLUSION After using for two weeks,captopril can recover circulatory homeostasis in patients with CHF, but has no effect on QTd.

参考文献/References

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[3] 胡大一. 慢性充血性心力衰竭药物治疗的现代观点与最新进展[J]. 中国实用内科杂志, 2000, 20: 6- 8.

[4] Day CP, Mccomb JM , Campbell RWF. QT dispersion : An indication of arrhythmia risk in patients with long QT intervals[J]. Br Heart J , 1990, 63: 342- 344.

[5] 钟　伟. 冠心病慢性心力衰竭QT 离散度分析[J]. 中国循环杂志, 1997, 12: 11.

[6] 傅　伟, 许亮文, 马　辉. QT 离散度与扩张型心肌病室性心律失常的关系[J]. 临床心血管病杂志, 2000, 16: 28- 29.

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[8] 刘克玲, 李庄平, 黄　玮. 依那普利治疗原发性高血压左室重构的疗效观察[J]. 临床心血管病杂志, 2000, 16: 37.

备注/Memo

备注/Memo:
收稿日期：2000-06-08.
更新日期/Last Update: 2001-09-01