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鼠胚胎干细胞体外分化的单个心肌细胞获取方法(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第5期
页码:
379-380
栏目:
论著
出版日期:
2001-09-01

文章信息/Info

Title:
The method to get single cardiomyocyte from embryonic stem cells differentiated in vitro
作者:
范　云1;  张建保2;  菅　中2;  龙开平2;  徐传镶1
1. 西安交通大学绝缘研究所, 陕西西安710049; 2. 第四军医大学物理学教研室
Author(s):
FAN Yun1;  ZHANG Jian-bao2;  JIAN Zhong2;  LONG Kai-ping2;  XU Chuan-xiang1
1.Insulation Institute, Xi’an Jiao Tong University, Xi’an Shaanxi 710049, China; 2. Department of Physics, Fourth Military Medical University
关键词:
胚胎干细胞;  心肌细胞;  分化;  体外
Keywords:
embryonic stem cells;  cardiomyocyte;  differentiation
分类号:
Q813.1
DOI:
-
文献标识码:
A
摘要:
用鼠胚胎干细胞在体外分化成心肌细胞是研究心肌细胞进化和生理学实验的新途径, 胚胎干细胞最初是从鼠胚胎在胚泡阶段或8 个细胞的胚胎阶段的内部没分化的细胞中得到。其可以定向诱导分化为几乎所有种类的细胞, 此文介绍了由鼠胚胎干细胞分化成为心肌细胞及单个心肌细胞的获取方法。
Abstract:
A new approach to study cardiomyogenesis is provided by the use of pluripotentmurine embryonic stem cells differentiated in vitro. The embryonic stem cells originally have been derived from undifferentiated cells of the inner cell mass of murine embryos at blastocyst stage or from eight-cell embryos. They have been shown to differentiate into all kinds of different cells. In this paper a method how to get single cardiomyocyte from embryonic stem cells differentiated in vitro has been in troduced.

参考文献/References

[1] Hescheler J , Fleischmann BK, Lentini S, et al. Embryonic stem cells: a model to study structural and functional properties in cardiomyogenesis[J]. Circ Res, 1997: 36: 149- 162.

[2] Wobus AM , Wallukat G, Hescheler J. Pluripotent mouse embryonic stem cells are able to differentiate into cardiomyocytes expressing chronotropic responses to adrenergic and cholinergic agents and Ca2+ channel blockers [J].Differentiation, 1991, 48: 173.

[3]Wobus AM , Holzhausen H, Jakel P, et al. Characterization of a pluripotent stem cell line derived from amouse embryo [J]. Exp Cell Res, 1984, 152: 212.

[4] 都同功, 陈系古, 刘兰英, 等. 小鼠胚胎干细胞的培养[J]. 中国实验动物学报, 1999, 7 (1) : 26 .

[5] 黄　冰, 黄文革, 钟女奇, 等. 小鼠胚胎干细胞在六种培养体系的培养观察[J]. 中国实验动物学报, 2000, 8 (1) : 1.

备注/Memo

备注/Memo:
收稿日期：2000-11-14.基金项目: 国家自然科学基金资助项目(No. 19902020)
更新日期/Last Update: 2001-09-01