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PTCA 手术前后患者TNF, TGF 和PGF 水平分析(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第2期
页码:
136-138
栏目:
临床研究
出版日期:
2002-03-01

文章信息/Info

Title:
Levels of plasma TNF, TGF and PGF in patients before and after PTCA
作者:
王晓红1;  贾国良1;  张　清1;  张荣庆1;  李家一1;  徐存华2
第四军医大学: 1. 西京医院心脏内科, 2. 校门诊部, 陕西 西安 710032
Author(s):
WANG Xiao-hong ;  JIA Guo-liang ;  ZHANG Qing ;  ZHANG Rong-qing ;  LI Jia-yi;  XU Cun-hua
Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032, China
关键词:
血管成形术;  经腔;  经皮冠状动脉;  肿瘤坏死因子;  转化生长因子;  前列腺素
Keywords:
angioplasty;  transluminal;  percutaneous coronary;  tumor necrosis factor;  transforming growth factor;  prostaglandin
分类号:
R451.4　
DOI:
-
文献标识码:
A
摘要:
目的 探讨 PTCA术前后血浆中肿瘤坏死因子 (TNF)、转化生长因子 (TGF-α) ,和 6 -酮 -前列腺素 F1α(6 - keto-PGF1α)的含量变化及临床意义。方法 PTCA患者 38例 ,分别于术前、术后 4h,12 h,抽外周血测定 TNF,TGF-α和 6 - keto- PGF1α值 ,对照组选取 CAG正常者 2 2例。结果 PTCA手术前后血浆中 TNF值均较 CAG正常组升高 ,TGF- α术前与 CAG正常组相同 ,术后升高。CAG正常组 6 - keto- PGF1α均高于 PTCA组 ,PTCA组术后只有轻度升高。放置支架越多 TNF,TGF- α值升高越明显 (P<0 。0 1)。结论 PTCA术后的血管反应与免疫因素有关。
Abstract:
AIM To investigate the plasma level changes of tumor necrosis factors(TNF), transforming growth factor(TGF-α), and prostaglandin(PGF) in patients with coronary heart disease before and after PTCA, and the clinical significance of it. METHODS 38 patients who underwent PTCA were brought into our study. Blood sample were collected during before, immediately, 4, and 12 h after PTCA to determine the plasma level of TNF, TGF-α and 6-keto-PGF 1α . Meanwhile 22 patients whose coronary arteriography showed normal were chosen to form control. RESULTS Plasma level of TNF rose in the PTCA group both before and after PTCA.TGF-α level was higher than control after PTCA , with the same level preoperatively. While 6-keto-PGF-α level was higher than PTCA group , the level in latter only slightly rose. The number of implanted stents had positive correlation with TNF, TGF-α, 6-keto-PGF-α(P < 0. 01). CONCLUSION Blood vessel responses after PTCA are correlated with immunologic factors, which would result in the occurrence of restenosis.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2001-02-13.
更新日期/Last Update: 2002-03-01