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胰岛素样生长因子1的系统生物学特性及其在冠心病发病中之作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第5期
页码:
433-434, 437
栏目:
综述与讲座
出版日期:
2002-09-01

文章信息/Info

Title:
-
作者:
朱志军 综述;  黄元伟 审校
浙江大学医学院附属第一医院心内科,浙江杭州310003
Author(s):
-
关键词:
胰岛素样生长因子1;  冠状动脉疾病
Keywords:
-
分类号:
Q578
DOI:
-
文献标识码:
A
摘要:
胰岛素样生长因子1(IGF1)是胰岛素家族中一员,近来发现在动物的体内存在着IGF1系统或IGF1轴,不仅作为内分泌系统中调节动物生长发育的一员,还通过自分泌、旁分泌机制参与多种生理及病理生理活动,其在冠心病的发生发展中也起了极其重要的作用。
Abstract:
-

参考文献/References

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[4] Jones JI,Clemmons DR. Insulin-like growth factors and their binding proteins:biological actions[J].Endocrinol Reb,1995,16:3-34.

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[6] Delafontaine P,Anwar A,Lou H. G-protein coupled and tyrosine kinase receptors:evidence that activation of the insulin-like growth factor-1 receptor is required for thrombin-induced mitogenesis of rat aortic smooth muscle cells[J].J Clin Invest, 1996,97:139-145.

[7] Chen WH,Pellegata NS,Wang PH. Coordinated effects of insulin like growth factor-1 on inhibitory pathways of cell cycle progression in cultured cardiac muscle cells[J]. Endocrinology, 1995,136:40-44.

[8] Donath MY,Zape J, Eppenberger-eberhardt M,et al. Insulin-like growth factor 1 stimulates myofibril development and decreases smooth muscle aplha-actin of adult cardiomyocytes[J].Proc Natl Acad Sci USA,1994,91:1681-1690.

[9] Sowers JR. Insulin and insulin-like growth factor in normal and pathological cardiovascular physiology[J]. Hypertension, 1997,29:691-699.

[10] Parrizas M,Sahei A,LeRoth D. Insulin-like growth factor-1 inhibition of apoptosis is associated with increased expression of the bcl-xL gene product[J] .Endocrinology, 1997,138:1355-1358.

[11] Hochberg Z,Hertz P,Maor G,et al. Growth hormone and insulin-like growth factor 1 increase macrophage uptake and degradation of low density lipoprotein[J]. Endocrinology, 1992,131:430-435.

[12] Martinez-gonzalez J,Vinals M,Vidal G,et al. Mevalonete deprivation impairs IGF insulin signaling in human vascular smooth muscle cells[J].Atherosclerosis,1997,135:213-223.

[13] Hayry P,Myllarniemi M,Aavik E,et al. Satabile D-peptide analog of insulin-like growth factor-1 inhibits smooth muscle cell prolifieration after corotid ballooning in the rat[J].FASEB J,1995,9:1336-1344.

[14] Leri A,Liu Y,Claudio PP,et al. Insulin-like growth factor-1 unduces Mdm2 and down regulates p53,attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis [J].Am J Pathol,1999,154:567-580.

备注/Memo

备注/Memo:
收稿日期：2001-03-13.
更新日期/Last Update: 2002-09-01