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|本期目录/Table of Contents|

延迟整流钾通道与动作电位复极及心律失常(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第6期
页码:
540-542
栏目:
综述
出版日期:
2002-11-01

文章信息/Info

Title:
-
作者:
石国忠 综述; 刘远谋 审校
上海第二医科大学生理学教研室,上海200025
Author(s):
-
关键词:
延迟整流钾通道; 动作电位复极; QT延长综合征
Keywords:
-
分类号:
R331.38;R541.7
DOI:
-
文献标识码:
A
摘要:
延迟整流钾通道(IK)主要参与心肌动作电位的复极过程。其至少包含两种成分:快速激活成分(Ikr)和缓慢激活成分(Iks)。目前IK通道的分子基础已趋阐明,HERG,KvLQT1或minK基因突变均可抑制IK流(Ikr或Iks),导致心肌复极延长,最终可产生QT延长综合征(LQTS)。
Abstract:
-

参考文献/References

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[2] Abbott GW,Sesti F,Slawski I,et al. MiRP1 forms Ikrpotassium channels with HERG and is associated with cardiac arrhythmia [J].Cell,1999,97:175-187.

[3] Pusch M,Magrassi R,Wollnik B,et al. Activation and inactivation of homomeric KvLQT1potassium channels[J].Biophys J,1998,75:785-792.

[4]李慈珍,王红卫,刘远谋,等.海蔡毒素对心肌钠通道开放模式、动作电位及心电图QT间期的影响[J].生理学报,2001,53(2):111-116.

[5] Chern-En C,Roden DM. The long QT syndrome:genetic basis and clinical implications[J].J Am Coll Cardiol,2000,36:1-12.

[6] Craig T,Qiuming G,Zhengfeng Z. Long QT syndrome:Cellular basis and arrhythmia mechanism in LQT2[J].J Cardiovasc Electrophysiol,2000,11(12):1413-1418.

[7] Zhou Z,Gong Q,January CT. Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome:Pharmacological and temperature effects[J].J Biol Chem,1999,274:31123-31126.

[8]Splawski I,Jiaziang S,Katherine W,et al. Spectrum of mutations in long QT syndrome genes KvLQT1,HERG,SCN5A,KCNE1 and KCNE2[J].Circulation,2000,102:1178-1185.

[9] Sanguinetti MC. Dysfuction of delayed rectifier potassium channels in an inherited cardiac arrhythmia[J].Ann N Y Acad Sci, 1999,868:406-413.

备注/Memo

备注/Memo:
收稿日期：2001-07-13.
更新日期/Last Update: 2002-11-01