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卡维地络对心绞痛患者白细胞表面CD11b及CD49d表达的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第1期
页码:
37-39
栏目:
临床研究
出版日期:
2003-01-01

文章信息/Info

Title:
The clinical affection of carvedilol to leucocytes cell adhere molecular CD11b and CD49d
作者:
秦涛1; 李虎1; 贾国良1; 郭文怡1; 吕安林1; 曹云新2
第四军医大学:1.西京医院心内科,2.中心实验室,陕西 西安710032
Author(s):
QIN Tao1; LI Hu1; JIA Guo-liang1; GUO Wen-yi1; Lu An-lin1; CAO Yun-xin2
1.Department of Cardiology,Xijing Hospital,Fourth Military Medical University,2.Central Lab of the Fourth Military Medical University,Xi'an,Shaanxi 710032,China
关键词:
卡维地络; 细胞间黏附分子; 白细胞; 流式细胞术
Keywords:
carvedilol; cellular adhesion molecules; leucocytes; flowcytometry
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:研究卡维地络对心绞痛患者外周血白细胞表面CD11b及CD49d表达的影响。方法:住院冠心病患者共48(男37,女11)例,其中稳定型心绞痛(SAP)22例,不稳定型心绞痛(UAP)26例,随机将SAP,UAP2组患者,各分为治疗组(给予卡维地络10mg口服,2/d,术前7d起使用)及对照组(给予美托洛尔12.5mg口服,2/d,术前7d起使用),分别于服药前及手术前采集股动脉血样,用FCM 直接免疫荧光法检测股动脉血中性粒细胞(Neu)、单核细胞(Mon)表面黏附分子CD11b及CD49d表达水平。结果:服药前两组CD11b及CD49d表达均无显著差异,UAP患者卡维地络组与美托洛尔组Neu与MonCD11b及CD49d均高于SAP患者组(P<0.05),服药7d后UAP组NeuCD11b卡维地络组明显低于美托洛尔组。结论:不稳定心绞痛Mon及NeuCD11b及CD49d表达均显著高于SAP。卡维地络降低Neu表面CD11b及CD49d表达,对Mon的影响尚有待评估。
Abstract:
AIM: To observe the clinical affection of carvedilol to peripheral leucocytes cell adhere molecular CD11b.METHODS:Femoral artery blood of 48 patients of UAP(26,14 Carvedilol and 12 Metoprolol)and SAP(22,11Carvedilol and 11Metoprolol)were selected before and 7d after treatment.Expression of CD11b and CD49d were measured by FCM.RESULTS:It was no deference between UAP and SAP group before therapy.Both granulates and monocytes CD11b and CD49d in UAP group is much higher than SAP group(P<0.01).After 7d therapy,CD11b and CD49d of granulates in UAP group treated by carvediol is much lower than metoprolol.(P<0.01).CONCLUSION:expression of CD11b and CD49d in leucocytesin UAP is higher than SAP.Carvedilol could down regulation CD11b expression in granulates.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2001-11-14.
更新日期/Last Update: 2003-01-01