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慢性心力衰竭患者血清TXB2,6-k-PGF1α和前列腺素E2测定及其意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第1期
页码:
34-36
栏目:
临床研究
出版日期:
2003-01-01

文章信息/Info

Title:
A study on the serum thromboxane B2,6-keto-PGF1αand prostaglandin E2 levels in chronic heart failure
作者:
季乃军; 应秀华; 梅益斌; 樊必夫; 王成尧; 陈东海; 管丽华; 高美英; 李建高
丽水市人民医院心内科,浙江 丽水32300
Author(s):
JI Nai-jun; YING Xiu-hua; MEI Yi-bin; FAN Bi-fu; WANG Cheng-yao; CHEN Dong-hai; GUAN Li-hua; GAO Mei-ying; LI Jian-gao
Department of cardiology,Lishui Hospital,Lishui,Zhejiang323000
关键词:
心力衰竭; 慢性; 血栓烷B2; 6-酮-前列腺素F1α; 前列腺素E2
Keywords:
heart failure chronic; thromboxane B2; 6-keto-PGF1α; prostaglandin E2
分类号:
R541.6
DOI:
-
文献标识码:
A
摘要:
目的:探讨慢性心力衰竭(CHF)患者血清血栓烷B2(TXB2)、6-酮-前列腺素F1α(6-k-PGF1α)和前列腺素E2(PGE2)水平的变化及其临床意义。方法:采用放射免疫法测定了108例CHF患者和30例非慢性心力衰竭患者的血清TXB2、6-k-PGF1α和PGE2水平,进行对照分析。结果:CHF组血清TXB2水平(86±8ng/L)显著高于对照组(49±6ng/L)(t=2.368,P<0.05),6-k-PGF1α水平(49±4ng/L)显著低于对照组(80±9ng/L)(t=3.526,P<0.01),PGE2无显著差异(P>0.05)。6-k-PGF1α与PGE2间呈显著正相关(r=0.316,P<0.01)。Ⅰ,Ⅱ,Ⅲ度CHF患者中,Ⅲ度组血清TXB2水平(114±18ng/L)显著高于Ⅰ度组(62±8ng/L)(t=2.368,P<0.05),其他组间血清TXB2,6-k-PGF1α和PGE2水平无显著差异(均P>0.05)。住院死亡组血清TXB2显著高于好转组(t=2.082,P<0.05),6-k-PGF1α和PGE2水平无显著差异(均P>0.05)。结论:CHF组血清TXB2水平显著高于对照组,6-k-PGF1α水平显著低于对照组,6-k-PGF1α与PGE2间呈显著正相关,观察血清TXB2,6-k-PGF1α和PGE2的变化,有助于CHF患者的病理机制、病情进展和预后的研究。
Abstract:
AIM: To explore the changes in serum thromboxane B2(TXB2),6-keto-PGF1α(6-k-PGF1α)and prostaglandin E2(PGE2) levels of patients with chronic heart failure(CHF),and clinical significiance of detecting them.METHODS:Serum TXB2,6-k-PGF1αand PGE2levels were determined by radioimmunoassay in 108 patients with CHF and 30 patients without CHF(control group).RESULTS:Compared with the control group,the serum TXB2 level in the CHF patients increased significantly (86±8ng/Lvs49.±6ng/L;t=2.368,P<0.05),andtheserum 6-k-PGF1α level decreased significantly(49±4ng/Lvs80±9ng/L;t=3.526,P<0.01),but no difference was defected in serum PGE2(P>0.05).There were significant correlations between the serum 6-k-PGF1α,PGE2 levels(r=0.316,P<0.01).Compared with the first degree group,the serum TXB2 level in the third degree group was higher(t=2.368,P<0.05).Compared with heal group,the serum TXB2 was highter(t=2.082,P<0.05),6-k-PGF1α and PGE2 were not significantly different(P>0.05).COCLUSION:Determining the levels of the serum TXB2,6-k-PGF1αand PGE2 in patients with CHF will be hilpful to the study of pathological mechanim.

参考文献/References

[1] 杨国雄, 张国忠, 李保罗. 血栓素A2和前列腺环素与自发性高血压大鼠高血压发展的关系 [J] . 中国病理生理杂志, 1991, (3):237-239.

[2] 刘海波, 陈在嘉, 高润霖, 等. 冠状动脉造影斑块形态与冠状循环中血浆及血清血栓素B2及6-酮-前列腺素F1α的关系 [J] . 中华心血管病杂志. 1996, 24(2):115.

[3] 丁怀翌. 冠心病患者血浆TXB2和6-酮-PGF1α浓度与冠脉病变的关系 [J] . 临床心血管病杂志, 1992, (1):11-13.

[4] 王成尧, 季乃军, 梅益斌, 等. 原发性高血压患者血清血栓素B2,6-酮-前列腺素F1α和胰岛素测定及其意义 [J] . 心脏血管病防治, 2001, 1(2):27-28.

备注/Memo

备注/Memo:
收稿日期：2001-09-11.
更新日期/Last Update: 2003-01-01