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卡维地洛对高血压大鼠心脏成纤维细胞胶原合成的抑制作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第3期
页码:
205-207,211
栏目:
实验研究
出版日期:
2003-05-01

文章信息/Info

Title:
The inhibitory effects of carvedilol on collagen syntheysis of cultured cardiac fibroblasts from SHR
作者:
张海涛1; 赵连友1; 王荫静2; 汪娜3; 田建伟1; 王士雯4
1.第四军医大学唐都医院心内科,陕西 西安710038;2.空军总医院临床试验中心,北京 100036; 3.北京空军医院特诊科,北京 100081;4.解放军第301医院老年心血管病研究所,北京 100853
Author(s):
ZHANG Hai-tao1; ZHAO Lian-you1; WANG Yin jing 2;  WANG Na 3;  TIAN Jian-wei1; Wang Shi-wen 4
1.Department of Cardiology,Tang du Hospital of Fourth Military Medical University,Xi'an, Shaanxi710038,China;2.General Hospital of AirForce,PLA,Bei jing100036,China;3.466th Hospital of PLA,Beijing100081,China;4.Institute of Geriatric Cardiology,General Hospitalof PLA,Bei jing 100853,China
关键词:
成纤维细胞; 心肌; 卡维地洛; 比索洛尔; 哌唑嗪; 胶原合成
Keywords:
fibroblasts; cardiac; carvedilol; bisoprolol; prazosin; collagesynthesis
分类号:
R541.3
DOI:
-
文献标识码:
A
摘要:
目的:探讨卡维地洛、比索洛尔、哌唑嗪对培养的SHR和Wistar大鼠心脏成纤维细胞(CFs)胶原合成的影响。方法:采用胰酶消化法培养CFs,用3H-脯氨酸掺入法分别观察卡维地洛、比索洛尔、哌唑嗪干预下两组大鼠CFs胶原合成的情况。结果:①各种浓度的卡维地洛(0.01～10μmol/L)可以浓度依赖的方式抑制CFs3H-脯氨酸掺入量,与Wistar大鼠组相比,SHR组CFs受抑制的效应更强。②同等浓度比索洛尔对两组大鼠CFs3H-脯氨酸掺入量表现出轻度抑制。③同等浓度哌唑嗪对两组大鼠CFs3H-脯氨酸掺入量均无明显影响。结论:卡维地洛呈浓度依赖性抑制CFs合成胶原,其作用机制部分与阻滞β1受体有关。
Abstract:
AIM:To evaluate the effects of carvedilol,bisoprolol and prazosin on collage synthesis of cultured rat cardiac fibroblast(CFs) derived from SHR(CFsSHR)and Wistar rats(CFsWis). METHODS:CFs derived from 12-week-old SHR and Wistar rats were cultured with enzymatic dissociation,and collagen synthesis was measured by 3H-Proline incorporation after incubation with carvedilol,bisoprolol and prazosin.RESULTS:①Carvedilol(0.01～10μmol/L)induceda significant concentration-dependent decreation in 3H-Proline incorporation in CFs derived from SHR and Wistar rats.②Bisoprolol(0.01～10μmol/L)caused a slight decrease in 3H-Proline incorporation.③ Prazosin(0.01～ 10μmol/L)treament had no effecton the 3H-Proline incorporation of all the cells. CONCLUSION:Dose-dependent carvedilol inhibites cardiac fibroblasts in vitro,which is partly due to the property of this selective β1-adrenergic receptor antagonist.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2002-9-10.
更新日期/Last Update: 2003-05-01