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|本期目录/Table of Contents|

阴离子替代和阴离子通道阻断剂对大鼠心率和心室收缩的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第3期
页码:
202-204
栏目:
实验研究
出版日期:
2003-05-01

文章信息/Info

Title:
Effects of Cl--substitution and Cl- channel blockers on rat heart rate and contraction
作者:
李耀秦; 顼红雨; 王跃民; 朱军; 周士胜
第四军医大学生理学教研室,陕西 西安710032
Author(s):
LI Yao-qin; XU Hong-yu; WANG Yue-min; ZHU Jun; ZHOU Shi-sheng
Department of Physiology,Fourth Military Medical University,Xi'an,Shaanxi710032,China
关键词:
Cl-通道; 心脏; 收缩; 大鼠
Keywords:
Cl- channel; heart; contraction; rat
分类号:
R331
DOI:
-
文献标识码:
A
摘要:
目的:探讨Cl-通道对大鼠离体心脏的心率和心室收缩的影响。方法:采用离体心脏Langendorff法灌流,监测心率和左心室内压的变化。结果:通透性较弱的阴离子替代细胞外液中的Cl-后,心率减慢和心室收缩减弱,Cl-通道阻断剂产生相似的结果。用高渗液灌流细胞后可以使室内压明显降低,但对心率的影响不明显。结论:Cl-通道在维持心脏的功能活动中有调节作用。
Abstract:
AIM:To explore the role of Cl- channels in the mechanical activities of perfusing isolated rat hearts.METHODS:The hearts was retrogradely perfused in a Langendorff apparatus under constant pressure.The left ventricular pressure(LVP) and ECG were recorded. RESULTS: Replacement of extracellular Cl- with glutamate or gluconate significantly decreased the heart rat and suppressed the development of LVP.Comparable effects were observed by using putative Cl- channel blocker 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB)and niflumic acid.Perfusion of the heart with hypertonic solution also induced inhibition of cardiac ventricular contraction but did not produced markedly influence on heart rate. CONCLUSION:Cl- channels play an important role in the cardiac mechanical activities.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2003-1-25.
更新日期/Last Update: 2003-05-01