我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

与Cibenzoline转复山羊持续性心房颤动相关的电生理现象分析(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第3期
页码:
223-225,229
栏目:
实验研究
出版日期:
2003-05-01

文章信息/Info

Title:
The electrophysiological phenomena associated with Cibenzoline-induced termination of atrial fibrillation in the goat
作者:
单兆亮1; 王玉堂1; 裴建明2; 时向民1; MauritsA.Allessi3
1.解放军总医院心内科,北京100853;2.第四军医大学生理学教研室,陕西西安710032;3.荷兰Maastricht心血管病研究所,Maastricht大学生理学系
Author(s):
SHAN Zhao-liang1; WANGYu-tang1; PEIJian-ming21; SHIXiang-min1; MauritsA.Allessie3
1.Department of Cardiology,General Hospital of PLA,Beijing100853,China
关键词:
心房颤动; 抗心律失常药; 标测
Keywords:
atrial fibrillation; antiarrhythmic drugs; mapping
分类号:
R541.75
DOI:
-
文献标识码:
A
摘要:
目的:在持续性心房颤动(房颤)山羊模型上,分析Ⅰ类抗心律失常药Cibenzoline使房颤转复为窦性心律时出现的电生理现象,探讨房颤转复的机制。方法:给7只山羊的左心房游离壁、左心耳、Bachmann氏束(BB)、右心耳及右心房游离壁缝合心外膜电极。用自动房颤刺激器维持房颤,待房颤持续4周后,静脉滴注Cibenzoline(0.1mg·kg-1·min-1),直至房颤终止。分析房颤转复前单极电图的形态特点、房颤周长(AFCL)的变化,并通过测量房颤周长的标准差(AFCLSD),分析心房激动均一性变化。结果:在房颤转复前最后2次心搏的平均AFCL有跳跃性延长(P<0.05),正常电位的百分率显著增加(P<0.05)。房颤转复前最后1个AFCLSD在除BB外的心房各部位内明显缩小(P<0.05),在整个心房内的变化不显著。结论:在房颤转复前的最后2次激动,房颤波激动的规律性明显增加,支持Ⅰ类抗心律失常药通过延长心房可兴奋间期而起作用的学说。
Abstract:
AIM:To investigate the electrophysiological phenomena associated with atrial fibrillation(AF) cardioversion by Cibenzoline in the goat,and try to explore the mechanism of AF termination by class I durgs. METHODS:Seven goats were chronically instrumented with epicardial electrodes in left atrium(LA),left atrial appendage (LAA),Bachmann'sbundle(BB), right atrial appendage (RA)and right atrium(RA).Persistent AF was induced by an automatic atrialfibrillator.AfterAFpersistedfor4weeks,Cibenzoline(0.1mg·kg-1·min-1)wasinfused until AF terminated.The percentage of normal potentials and AF cycle length (AFCL) in the last 30 beats before cardioversion were evaluated.The standard deviation of AFCL(AFCLSD)in the last 10 beats were compared intrarregionally and interregionally.RESULTS:Compared with previous beats,in the last 2 AF beats there were dramatic prolongation of AFCLs and increase of narmal potentials (P<0.05).Except for BB,the standard deviation of the last AFCL dectreased regionally (P< 0.05),but there was no significant change interrgionally(P> 0.05). CONCLUSION:In the last 2 beats before cardioversion,the activation of AF wavelets became highly organized,which may support the hypothesis that the termination of AF by class I drugs is caused by prolonging the excitable period

参考文献/References

[1] Wang Z,Page PL,Nattel S. Mechanism of flecainide's antiarrhythmic action in experimental atrial fibrillation[J].CircRes,1992,71:271.

[2] Kirchh of CJHJ,Wijffels M,Brugada J,et al.Mode of action of a new class Ic drug (ORG 7797) against atrial fibrillation in conscious dogs [J].J Cardiovasc Pharmacol,1991,17:116.

[3] Wijffels MCEF, Dorland R,Mast F,et al.Widening of the excitable gap during pharmacological cardioversion of atrial fibrillation in the goat: effect of cibenzoline,hydroquinidine,flecainide,and d-s otalol [J]. Circulation,2000,102:20.

[4] MoeGK. On the multiple wavelets hypothesis of atrial fibrillation [J]. Arch Int Pharmacodyn Ther, 1962,140:183.

[5] Wijffels MCEF,Kirchh of CJHJ , Dorland R,etal. Atrial fibrillation begets atrial fibrillation:a study in awake chronically instrumented goats[J].Circulation,1995,92: 1954.

[6]CaloL,RiccardiR,ScaglioneM,et al. Extensive biatrial mapping of spontaneous termination of human atrial fobrillation [Abstract][J].Eur HeartJ,2000,21:543.

[7] Browne KF, Prystowksky EN, Zipes DP,et al.Clinical efficacy and electrophysiologic effects of cibenzoline therapy in patients with ventricular arrhythmias [J].J Am Coll Cardiol,1984,3:857.

[8] Danse PW,Garratt CJ,Mast F,et al.Preferential depression of conduction around a pivot point in rabbit ventricular myocardium by potassium and flecainide[J].J Cardiovasc Electrophysiol, 2000, 11:262.

[9]Konings KTS, Smeets JLRM, Penn OC, et al. Configuration of unipolar atrialel ectrograms during electrically induced atrial fibrillation inhumans [J].Circulation,1997,95:1231.

[10]Sih HJ,RopellaKM,Swiryn S,etal. Observation from intraatrial recordings on the termination of electrically induced atrial fibrillation in humans[J].PACE,1994,17:1231.

[11] Brugada J,Brugada P,Guiraudon G,etal. Cibenzoling transforms random re-entry into order re-entry in the atrial [J].Eur HeartJ, 1993, 14: 267.

备注/Memo

备注/Memo:
收稿日期：2002-2-13.
更新日期/Last Update: 2003-05-01