小、中剂量阿司匹林对AMI的疗效及其与抗炎作用的关系(PDF)
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2003年第3期
- 页码:
- 226-229
- 栏目:
- 实验研究
- 出版日期:
- 2003-05-01
文章信息/Info
- Title:
- The therapeutic effects of low-and moderate-dose aspirin on rabbits with experimental acute myocardial infarction and their relationship with antinflammatio
- Author(s):
- HUANG Xiao-zhong; YANG Xin-guo; MIAO Ya
- Department of Cardiology,Tang du Hospital,Fourth Military Medical University,Xi'an, Shaanxi 710038,China
- Keywords:
- aspirin; dose; acutemyocardialinfarction; inflammation
- 分类号:
- R542.22
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的:评价小、中剂量阿司匹林对急性心肌梗死(AMI)的治疗作用及其机制。方法:将体质量1.5～2.5kg的成年兔36只随机分为对照组(A组)、阿司匹林小剂量组(B组)及中剂量组(C组),建立AMI模型并给予相应的干预,术后6h作血液学观察,4d及4周时分别作血液、血清、血流动力学、大体形态测量及组织学的观察。结果:B,C组与A组比较,术后6h血白细胞数无明显差异(P>0.05),而4d及4周时明显下降(P<0.05),一氧化氮在术后4d及4周时均无明显差(P>0.05),心房钠尿肽、左室功能测定值、左室舒张末压均明显下降(P<0.05),术后4d梗死面积明显下降(P<0.05),但4周时修复后瘢痕的面积无明显差异(P>0.05),以上指标B、C组间无明显差异(P>0.05)。4周时B组瘢痕厚度与A组无明显差异(P>0.05),但C组厚度明显变薄(P<0.05)。组织学检查显示A组梗死区术后4d心肌结构消失,中性粒细胞大量浸润,B,C组白细胞浸润程度与A组无明显差异,但B组梗死区中有少许坏死心肌组织,C组则残存较多的坏死心肌组织。结论:小剂量阿司匹林对AMI治疗作用优于其中等剂量。
- Abstract:
- AIM:To investigate the mechanism underlying the effects of low-and moderate-dose aspirin on rabbits with experimental acute myocardial infarction and their clinical significance. METHODS:Adult rabbits (weight:1.5～2.5kg,n=36)were randomLy divided into three groups: group A undergoing all procedures except treatment,group B receiving the treatment of low-dose aspirin,group C receiving the treatment of moderate-dose aspirin.The specimens harvested at 6hours, 4 days and 4 weeks after AMI,were measured and studied under the microscope. RESULTS:The blood leukocyte count in the three groups were similar at the first 6 hours after AMI,but those in group B,C were significantly reduced compared with those in group A 4 days and 4 weeks after AMI.In group B and C,NO was similar to that of group A,butANP, STI, LVEDP were significantly decreased compared with those of group A. Myocardial infarct sizes in group B and C were significantly decreased 4 days after AMI,while were similar to group A 4 weeks after AMI.Scar thickness in group B did not differ from that in group A, but in group C the scar thickness was thinner than that in group A 4 weeks after AMI. Light microscopic examination of myocardial infarct area revealed similar leukocytic infiltration in three groups,with no structure of necrotic myocardium in group A,a little in group B and much in group C 4 days after AMI.CONCLUSION:The theraputic effects of aspirin in a low dose on AMI maybe better than that in a moderate dose.
参考文献/References
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备注/Memo
- 备注/Memo:
- 收稿日期：2002-10-21.
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