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|本期目录/Table of Contents|

血管内皮生长因子在肺动脉平滑肌细胞重构中的作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第6期
页码:
495-497
栏目:
实验研究
出版日期:
2003-11-01

文章信息/Info

Title:
The role of vascular endothelial growth factor in monocrotaline-induced pulmonary hypertension
作者:
宋景春; 李志超; 赵澎涛; 刘毅
第四军医大学病理生理学教研室, 陕西 西安 710032
Author(s):
SONG Jing-chun;  LI Zhi-chao;  ZHAO Peng-tao;  LIU Yi
Department of Pathophysiology, Fourth Military Medical University, Xi’an, Shaanxi 710032, China
关键词:
血管内皮生长因子; 高血压;  肺动脉; 野百合碱; 大鼠
Keywords:
vascular endothelial growth factor;  pulmonary hypertension;  monocrotaline;  rats
分类号:
R972.4　
DOI:
-
文献标识码:
A
摘要:
目的:探讨血管内皮生长因子(VEGF)在野百合碱(MCT)性肺动脉高压(PH)中的作用。方法: 用MCT复制大鼠慢性PH病理模型, 用免疫组化法和图像分析技术测定肺组织中V EGF 的表达。结果: 发现V EGF 可在正常大鼠肺血管平滑肌、支气管平滑肌和软骨组织中表达, 并且MCT 组V EGF 表达的相对含量在肺血管平滑肌(177±7) 和支气管平滑肌(172±6) 均较正常组(血管平滑肌136±8, 支气管平滑肌138±12) 呈显著增强(P<0.05)。结论:MCT 性PH 中V EGF 在肺血管平滑肌的过度表达参与MCT性PH 的发病过程。
Abstract:
AIM: To explore the role of vascular endothelial growth factor (VEGF) in monocrotaline-induced pulmonary hypertension. METHODS: VEGF was investigated by using immunohistochemistry and image analysis on the chronic pulmonary hypertension (PH) induced by MCT in Sprague-Daw ley rats. RESULTS: VEGF was positive in pulmonary vascular smooth muscle cells, bronchial smooth muscle cells and chondrocytes in the control group. VEGF in the MCT group was more prominent in pulmonary vascular smooth muscle cells and bronchial smooth muscle cells as compared with the control. CONCLUSION: Over expression of VEGF in pulmonary vascular smooth muscle cells and bronchial smooth muscle cells is related to MCT-induced PH.

参考文献/References

[1] Millhorn DE, Raymond R, Conforti L, et al. Relation of the rat vascular endothelial growth factor gene by hypoxia [J] . J Biol Chem, 1995, 270(20):13333-13340.

[2] Li ZC, Zhang FQ, Song JC, et al. Therapeutic effects of DCDDP, a calcium channel blocker, on chronic pulmonary hypertension in rat [J] . J Appl Physiol, 2002; 92(3):997-1003.

[3] Forsythe JA, Jiang BH, Iyer NV, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1 [J] . Circ Res, 1996, 16(9):4604-4613.

[4] Taraseviciene-Stewart L, Kasahara Y, Alger L, et al. Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension [J] . FASEBJ, 2001, 15(2):427-438.

[5] Mamputu JC, Renier G. Advanced glycation end products increase, through a protein kinase C-dependent pathway, vascular endothelial growth factor expression in retinal endothelial cells. Inhibitory effect of gliclazide [J] . J Diabetes Complications, 2002, 16(4):284-293.

[6] Cassano A, Bagala C, Battelli C, et al. Expression of vascular endothelial growth factor, mitogen-activated protein kinase and p53 in human colorectal cancer [J] . Anticancer Res, 2002, 22(4):2179-2184.

备注/Memo

备注/Memo:
收稿日期：2002-12-10.
更新日期/Last Update: 2003-11-01