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降钙素基因相关肽对血管升压素缩血管效应的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第6期
页码:
493-494
栏目:
实验研究
出版日期:
2003-11-01

文章信息/Info

Title:
The effect of calciton in gene-related peptide on vasoconstriction induced by rginine vasopressin
作者:
叶季鲜1; 李红梅1; 黄静1; 赵连友2
1.解放军323医院心内科, 陕西 西安 710054; 2.第四军医大学唐都医院心内科
Author(s):
YE Ji-xian1;  LI Hong-mei1;  HUANG Jing1;  ZHAO Lian-you2
1.Department of Cardiology, 323 Hospital of PLA, Xi’an, Shaanxi 710054, China
关键词:
降钙素基因相关肽; 血管升压素; 血管平滑肌细胞; 细胞内游离钙
Keywords:
calcition gene-related peptide;  arginine vasopressin;  vascular smooth muscle cells;  cytosolic free Ca2+
分类号:
R331.32
DOI:
-
文献标识码:
A
摘要:
目的:探讨降钙素基因相关肽(CGRP)对血管升压素(AVP) 缩血管效应的影响。方法: 培养大鼠主动脉血管平滑肌细胞(VSMC), 给予AVP和CGRP干预, 检测VSMC的细胞内游离钙离子浓度([Ca2+]i)。结果:AVP 增加VSMC的[Ca2+]i, 而CGRP明显抑制AVP的这一作用。结论: CGRP可能通过抑制VSMC的[Ca2+]i 的升高而发挥其对AV P 所致缩血管效应的抑制作用。
Abstract:
AIM: To investigate the effect of calciton in gene-related peptide (CGRP) on the vasoconstriction induced by arginine vasopressin (AVP). METHODS: The aortic vascular smooth muscle cell (VSMC) of rat was cultured to determine the cytosolic free Ca2+ concentration ([Ca2+]i) in the presence of CGRP and AVP. RESULTS: AVP increased [Ca2+]i, which was significantly attenuated by CGRP. CONCLUSION: CGRP plays the inhibitory effect on AVP-induced vasoconstriction by confining increased [Ca2+]i of VSMC.

参考文献/References

[1] 叶季鲜, 李红梅, 黄静, 等. 高血压病患者血浆降钙素基因相关肽和内皮素浓度的变化 [J] . 心脏杂志, 2001, 13(3):188-189, 192.

[2] Lappe RW. Hemodynamic effects of calcitonin gene-related in conscious rats [J] . Regulpept, 1987, 19:307-313.

[3] Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluoresence properties [J] . J Biol Chem, 1985, 260:3440-3450.

[4] 赵连友, 曹世平. 高血压患者血浆精氨酸加压素浓度的变化及其与病情的关系 [J] . 中华心血管病杂志, 1993, 21(3):147-149.

[5] 李红梅, 裴建明, 朱妙章, 等. 降钙素基因相关肽的抗室颤作用 [J] . 心功能杂志, 1997, 9(1):5-7, 10.

[6] 吴宏超, 钱学贤, 李立平. 降钙素基因相关肽对顿抑心肌心功能的影响 [J]. 心功能杂志, 1999, 11(4):220-221, 224.

[7] Gangule PR, Supowit SC, Wimalawansa SJ, et al. Calcitonin gene-related peptide is a depressor in NG-nitro-L-arginine methylester-induced hypertension during pregnancy [J] . Hy-pertension, 1997, 29(1pt2):248-253.

[8] Gopalakrishnan V, Xu YJ, Sulakhe PV, et al. Vasopressin (V1) receptor characteristics in rat aortic smooth mucle cell [J] . Am J Physiol, 1991, 261 (Heart Circ, Physio l,30):H1927-H1936.

备注/Memo

备注/Memo:
收稿日期：2002-09-09.
更新日期/Last Update: 2003-11-01