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|本期目录/Table of Contents|

8Hz、90dB次声对一氧化氮分泌和血管内皮生长因子表达的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第1期
页码:
20-22
栏目:
实验研究
出版日期:
2004-01-01

文章信息/Info

Title:
The effects of infrasound on these cretion of the nitric oxide in rat plasma and the expression of VEGF invascular endothelia
作者:
裴兆辉1; 陈景藻2; 朱妙章1; 刘 静3; 张 强4
第四军医大学:1.基础部生理学教研室,2.预防医学系,3.西京医院理疗与康复医学科, 4.唐都医院骨科,陕西 西安 710033
Author(s):
PEI Zhao-hui1; CHEN Jing-zao2; ZHU Miaohang1; Liu Jing3; ZHANG Qiang4
1.Deparment of physiology, Fourth Military Medical University, Xi'an, Shaanxi 710033,China
关键词:
次声; 大鼠; 一氧化氮; 内皮生长因子
Keywords:
infrasound;  rats;  nitric oxide;  vascular endothlial growth factor
分类号:
X121;Q463
DOI:
-
文献标识码:
A
摘要:
目的:测定 8Hz、90dB次声多次暴露后大鼠血浆一氧化氮(NO)的含量变化及内皮生长因子(VEGF)表达的改变。方法:用 8Hz、90dB的次声连续作用大鼠 1、7、14、21、28d,每天 2h,测定大鼠血浆NO含量和VEGF表达的变化。结果:次声暴露1、7d,大鼠血浆 NO含量无变化,14、21d时降低(P<0.05), 28d时恢复正常(P>0.05);在次声暴露期与对照组比较,VEGF表达增强(P<0.01)。结论:次声可引起大鼠血浆NO分泌的变化及 VEGF表达改变,其与次声暴露的时间和量有关。
Abstract:
AIM:To oberve the changes of NO in plasma of rats and the VEGF expression in vascular endothelia. METHODS:The rats in the expoesd groups were affeted by infrasound (frequency:8 Hz; sonud pressure level: l30dB, 2 h daily), and the contents of NO and the epressions of VEGF in the exposed groups and control group were measured. RESULTS: The changes of NO contents declined on 14th d and 21st d(P<0.05), and there was no change on 1st d, 7th d and 28th d(P>0.05). The exprssions of VEGF were inceased in the exposed all group, compared with the control goup(P<0.01). CONCLUSION: Infrasound can induce changes in NO secretion and VEGF exprssion, and they depend on the amount and duration of infrasound expsure.

参考文献/References

[1]陈景藻. 次声的产生及生物学效应[J].国外医学物理学与康复分册,1999,19:15-17.

[2]唐朝枢,汤健. 一氧化氮与疾病[J].中华医学杂志,1998,78:5.

[3]Feng YY,Venema VJ,Venema RC,et al. VEGF induces nuclear transcation of FIK-1/KDR, endothelial nitric oxide synthase and canelin-1 invascular endothelial cells[J]. Biochem,1999,256(1):192-197.

[4]Nekhoroshev AS,Glinchikov VV. Morphofunctional changes in the myocardium under exposure to infrasound[J]. NVB Noise Vib Bull,1991,(12):56-58.

[5]荀琳,张作明,郭守一.次声作用对大鼠视网膜Müller细胞及血管内皮细胞增殖力的影响[J].中华航空航天医学杂志,2002,13(1):53-56.

[6]王冰,郭 群,李 莉.次声作用后大鼠视网膜组织中GFAP与VEGF的表达[J].眼外伤职业眼病杂志,2002,1(1):45-48.

[7]Liu YX,Christou H,Morita T. Carbonmon oxide and nitric oxide suppress the hypoxic induction of VEGF gene via the 5' enhancer[J].Biol Chem,1998,273:15257-15262.

[8]Jzef D,Jzkowicz A.Nitric oxide and angiogenic activity of endothelial cells: direct or VEGF dependent effect?[J], Cadioasc Res,2002,56(3):487-488.

备注/Memo

备注/Memo:
收稿日期：2003-8-21.
更新日期/Last Update: 2004-01-01