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卡维地洛治疗高龄老年人心力衰竭的临床观察 (PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第1期
页码:
43-44
栏目:
临床研究
出版日期:
2004-01-01

文章信息/Info

Title:
Observation on therapeutic effectiveness of Cavedilol in the elderly patients with heart failure
作者:
丁一妹1 张 延2 英明中1 武 强1
1.解放军总医院老年心内科,北京 100853;2.解放军 305医院,北京 100017
Author(s):
DING Yi-mei1 ZHANG Yan2 YING Ming-zhong1 WU Qiang1
Department of Geriatric Cardiologiy, 301 Hospital of PLA, Beijing 100853, China
关键词:
卡维地洛心力衰竭老年人高龄
Keywords:
Cavedilol heart failure aged elderly
分类号:
R541.6
DOI:
-
文献标识码:
A
摘要:
目的:观察卡维地洛(β受体阻滞剂)对高龄老年人心力衰竭的影响。方法:选择心功能Ⅱ,Ⅲ级的高龄(大于80岁)老年患者 25例,除外哮喘、支气管痉挛的慢性阻塞性肺疾病、肝功能异常、Ⅱ~Ⅲ度房室传导阻滞、严重心动过缓、严重低血压。入选后每周观察心率和血压;患者在常规抗心衰治疗基础上加服卡维地洛,服卡维地洛前和服后8周分别作超声心动图进行比较。结果:治疗前后患者心率、血压显著降低(P<0.01),左室射血分数(LVEF)及二尖瓣波群 E/A显著增加(P<0.05,P<0.01),等容舒张时间(LVRT)显著缩短(P<0.01)。结论:高龄老年心力衰竭患者在常规抗心衰治疗基础上加用卡维地洛,可进一步改善心功能,提高生活质量。
Abstract:
AIM: To evaluate the therapeutic effectiveness of Cavedilol on the elderly patients with heart failure. METHODS: 25 elderly patients with Ⅱ-Ⅲ degree cardiac function(≥80 years of age) were given Caedilol for 8 weeks. Before and after the treatment, heart rate, blood pressure,echocardiograpy were performed respectively. RESULTS: Eigt weeks after the treatment LVEF and E/A were increased (P<0.01) while the heart rate, blood pressure and LVRT were reduced (P<0.01). CONCLUSION: Cavedilol added to conventional therapy can improve cardiac function and living quality in the elderly patients with heart failure.

参考文献/References

[1]Packer M,Bristow WR.Effect of Carvedilol on morbidity and mortality in chronic heart failure[J]. N Engl J Med,1996,334(6):1349.

[2]朱文青.2002年肾上腺能阻滞剂在心血管病中的临床应用国际研讨会简介[J].中华心血管病杂志,2002,30(7):439.

[3]张利华,薛玉生,赵季红,等.卡维地洛与美多心安治疗稳定型心绞痛的临床疗效比较[J].心脏杂志,2002,14(6):488-490.

[4]曾佑平,张利华.卡维地洛治疗扩张型心肌病复杂型室性心律失常的疗效评价[J].心脏杂志,2002,15(2):121-123.

[5]江一清.新型β受体阻滞剂-卡维地洛[].心血管病学进展,1998,19(2):132.

[6]Dunv CJ, Lea AP,Wagstaff AT. Carvedilol Areappraisal of its pharmacological properties and therapeutic use in cardiovascular disorders[J]. Drugs,1997,54:1161.

备注/Memo

备注/Memo:
收稿日期:2002-12-30
更新日期/Last Update: 2004-01-01