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|本期目录/Table of Contents|

S100蛋白与心脏术后脑损伤(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第2期
页码:
169-171,174
栏目:
综述
出版日期:
2004-03-01

文章信息/Info

Title:
-
作者:
郭正纲综述; 张英民审校
解放军304医院, 北京 100037
Author(s):
-
关键词:
S100蛋白; 心血管外科; 并发症
Keywords:
-
分类号:
R654.2;R651.15
DOI:
-
文献标识码:
A
摘要:
血清S100蛋白是早期脑损伤的重要标记物,心脏手术后测定其血清浓度有助于诊断脑损伤。心肺转流(CPB)后S100蛋白水平升高与围术期的脑部并发症,如中风、苏醒延迟和昏迷直接相关,也与心脏手术后的神经功能障碍有关。在CPB术后,S100蛋白有早期释放和晚期释放两种形式:早期释放可能是由于亚临床脑损伤所引起;晚期释放可能与围术期脑部并发症有关。在转流前应用动脉导管过滤及使用共价连结肝素涂层转流导管内壁,患者CPB后血清S100蛋白水平升高不明显。在非心脏手术中亦可检测到S100蛋白的释放,其水平的升高与颅脑损伤、急性中风以及心搏骤停有关。
Abstract:
-

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2003-5-30
更新日期/Last Update: 2004-03-01