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曲美他嗪对稳定型心绞痛血管内皮功能的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第4期
页码:
315-317
栏目:
临床研究
出版日期:
2004-07-01

文章信息/Info

Title:
The effects of Trimetazine angina on vascular endothelial function of stable
作者:
杨海玉1; 曾玉杰2; 黄占军2
1.江门市中心医院，广东 江门 529070; 2.中日友好医院，北京 100029
Author(s):
YANG Hai-yu1; ZENG Yu-jie2; HUNG Zhan-jun2
1.Ji angmenC entralH ospital，Jiangmen，Guangdong 529070, China; 2. China-Japan Friendship Hospital，Beijing 100029,China
关键词:
曲美他嗪; 心绞痛; 内皮; 血管舒张
Keywords:
Trimetazine; angina;  endothelium;  vasodilatation
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:探讨曲美他嗪对稳定型心纹痛血管内皮功能的影响。方法:稳定型心纹痛60例，随机分为2组，对照组常规服用硝酸醋类、钙离子拮抗剂、β受体阻滞剂、血小板抑制剂;曲美他嗪组在服用以上药物的基础上加用曲美他嗪(20 mg)，每日3次，服4周。采用高分辨超声技术检测脸动脉舒张功能，测定两组基础状态和治疗后的血浆一氧化氮(NO)、内皮素-1(ET-1)水平.结果:①反应性充血引起脸动脉内径变化，曲美他嗪组显著增强(P<0.01).两组含服硝酸甘油后的血管舒张反应无显著差异(P>0.05).②治疗后，曲美他嗪组与对照组比较NO显著升高，ET-1水平下降，有非常显著性差异(P<0.01 ).结论:曲美他嗪对稳定型心纹痛血管内皮功能具有保护作用。
Abstract:
AIM:To investigate the effects of Trimetazine on vascular endothelial function of stable angina. METHODS:With high resolution ultrasound，flow and nitroglycerin-induced dilation of the brachial artery was measured in 30 stable angina (control group)and 30 stable angina with trimetazine (trimetazine group)，both serum NO and endothelial-1 levels were determined at the same time. RESULTS:(D1 The flow-induced vasodilatation in the Trimetazine group was significantly increased compared with thatin the control group(P<0.01).However,vasodilitation in response to nitroglycerin was similar in both groups (P>0.05);②Plasma endothelial-1 level in the Trimetazine group was significanty lower than that in the control group (P<0.01);Plasma NO level in the Trimetazine group was significanty higher than that in the control group (P<0.01). CONCLUSION:Trimetazine can improve the vascular endothelial function of stable angina.

参考文献/References

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[6] 中国曲美他嗪中心临床研究协作组.曲美他嗪对稳定劳力型心纹 痛 的 疗效观察[J].中华心血管病杂志，2000,28:339-441.

[7] Kantor PF, Lucien R, Kozak R, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme athiolase[J].Circ Res,2000,86:580-588.

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备注/Memo

备注/Memo:
收稿日期：2003-11-20
更新日期/Last Update: 2004-07-01