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高血压病患者淋巴细胞肾上腺素能β2 受体密度与心脏不同几何构型的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第5期
页码:
467-469
栏目:
临床研究
出版日期:
2004-09-01

文章信息/Info

Title:
The relationship between beta2-adrenoreceptor density and different left ventricular geometry in patients with essential hypertension
作者:
张延斌;  朱　红;  王红雷;  潘德锋;  李东野;  陈清枝
徐州医学院附属医院心内科,江苏徐州221002
Author(s):
ZHANG Yan-bin ;  ZHU Hong ;  WANG Hong-lei ;  PAN De-feng ;  LI Dong-ye ;  CHEN Qing-zhi
Department of Cardiology , Affiliated Hospital of Xuzhou Medical College , Xuzhou , Jiangsu 221002 , China
关键词:
高血压; β2 受体;  左室重构
Keywords:
essential hypertension ;  beta2-adrenoreceptor ;  left ventricular remodeling
分类号:
R544. 1
DOI:
-
文献标识码:
A
摘要:
目的:研究高血压病患者外周血淋巴细胞β2 受体密度与心脏不同几何构型之间的关系。方法:采用放射性配基结合分析法,测定不同心脏构型高血压病患者91 例外周血淋巴细胞的β2 受体密度,并与正常人31 例对照。结果:与对照组比较,向心性重构(CCR) 及向心性肥厚(CCH) 组β2 受体密度显著增加,离心性肥厚( ECH) 组β2 受体密度显著减少,而正常几何构型(NG) 组无明显变化。结论:高血压病患者外周血淋巴细胞β2 受体密度与其心脏的几 何构型有关。
Abstract:
AIM: To study the relationship between beta2-adrenoreceptor density and different left ventricular geometry in EH patients. METHODS : 91 EH patients were included in study and 31 healthy subjects were used as control . beta2-adrenoreceptor maximum bound volume (β2max) in peripheral lymphocytes was measured by 3H-DHA radio ligand binding. Left ventricular geometry was studied by using two2dimensional echocardiography. RESULTS :β2max was significantly higher in the CCR and CCH groups of the EH patients than the normotensive control subjects , but was significantly lower in the ECH group and there was no significant change in the NG group. CONCLUSION:β2max was correlated with left ventricular remodeling and left ventricular systolic function in the patients EH. Its change could reflect the forms of left ventricular remodeling.

参考文献/References

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[2 ] Devereux RB , Alonso DR , Lelas EM, et al . Echocardiographic assessment of left ventricular hypertrophy :comparison to necropsy finding[J ] .Am J Cardiol ,1986 ,57 :450 - 457.

[3 ] Ganau A , Devereux RB , Roman MJ , et al . Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension [J ] . J Am Coll Cardiol , 1992 ,19 : 1550 - 1558.

[4 ] 单精瑞,付国辉,吕宝璋. 外周血淋巴细胞肾上腺素能受体的放射性配基结合分析法[J ] . 军事医学科学院院刊,1988 ,1 :73 - 77.

[5 ] 陈富荣,余细勇,黄文辉,等. 临界高血压患者淋巴细胞β2 受体密度与β阻断剂治疗变化的研究[J ] . 高血压杂志,2000 ,8 (2) :134 - 135.

[6 ] 彭应心,马淑平,李玉龙,等. 高血压不同时期β受体的变化及其意义[J ] . 中华心血管病杂志,1999 ,27(1) :48 - 50.

[7 ] Peng Y,Ma S ,Zhang S , et al . Clinical significance of changes in beta-a-drenoreceptors in peripheral lymphocytes in patients with essential hypertension[J ] . Chin Med J ( Engl) ,2000 ,113(12) :1064 - 1067.

[8 ] 边树怀,马淑平,刘坤申,等. 高血压病淋巴细胞β2 受体的变化及卡托普利对该受体的影响[J ] . 高血压杂志,1998 ;6 (4) : 249-251.

[9 ] 卢永昕,董　琳,杨　娅,等. 高血压左室肥厚与外周血淋巴细胞β2 受体密度的关系[J ] . 高血压杂志,1998 ;6(1) : 25 - 27.

备注/Memo

备注/Memo:
收稿日期：2003-11-8
更新日期/Last Update: 2004-09-01