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氨氯地平干预兔动脉粥样硬化过氧化脂质代谢、前列环素/ 血栓烷A2 平衡异常的研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第6期
页码:
517-519,522
栏目:
基础研究
出版日期:
2004-11-01

文章信息/Info

Title:
The abnormal ities of l ipid peroxidate metabol ism, PGI2/ TXA2 equil ibrium and anti- effects of amlodipine in arteriosclerotic rabbits
作者:
马建林1; 毛焕元2; 周本财2; 周顺长2
1. 海南省人民医院心内科,海南海口570311 ;2. 华中科技大学同济医学院心血管研究所,湖北武汉430022
Author(s):
MA Jian-lin1; MAO Huan-yuan2; ZHOU Ben-cai2; ZHOU Shun-chang2
1. Department of Cardiology , Hainan Province People′s Hopital , Haikou , Hainan 570311. 2. Institute of Cardiovascular Diseases , Tongji Medical college , Huazhong University of Science andTechnology , Wuhan , Hubei 430022
关键词:
动脉粥样硬化; 脂质过氧化; 氨氯地平; PGI2/ TXA2 平衡
Keywords:
arteriosclerosis ;  lipid peroxidate ;  amlodipin ;  PGI2/ TXA2 equilibrium
分类号:
R541. 4 　
DOI:
-
文献标识码:
A
摘要:
目的: 观察动脉粥样硬化(AS) 兔过氧化脂质代谢、前列环素(PGI2) / 血栓烷A2 ( TXA2 ) 平衡异常以及氨氯地平干预作用。方法:采用高脂饲料或高脂饲料加氨氯地平喂养家兔60 d ,喂养前、后抽血测生化指标,喂养后处死动物作组织学研究。结果: 喂养后血清总胆固醇( TC) 、主动脉和血浆丙二醛(MDA) 、全血血小板活化因子( PAF) 、血浆TXB2 、内皮素( ET) 水平显著升高,血小板聚集性增强,而主动脉组织和血浆6-酮-前列腺素(6-Keto-PGF1α) 、血浆超氧化物歧化酶(SOD) 水平显著下降,并且发生AS 病变。氨氯地平可以降低MDA 及ET 含量,提高PGI2/TXA2 比值,减轻AS 病变。结论:AS 家兔体内出现脂质过氧化代谢异常、PGI2/ TXA2 平衡失调,而氨氯地平具有明显的拮抗作用,其机制可能与抗氧化有关。
Abstract:
AIM: To observe the abnormalities of lipid peroxidate metabolism , Prostaglandin I2 (PGI2) /Thromboxane A2 ( TXA2 ) equilibrium and anti-effect s of amlodipine. in arteriosclerotic rabbit s.METHODS :Rabbit s were food with high cholesterol diet or high cholesterol diet plus amlodipine for 60 days , and items of the blood were measured before as well as after the feeding times , and the rabbit s were killed for histologic study. RESULTS :Levels of blood serum total cholesterol , aorta and blood plasma malondialdehydin (MDA) , whole blood platelet activiting factor , plasma TXB2 , endothelin , and platlete aggregation were significantly increased , whereas levels of aorta as well as blood plasma 6-Keto- prostaglandin F1α , plasma superoxide dismutase were significantly decreased , and with occurrences of arteriosclerosis , and amlodipin could lower levels of MDA and endothelin , increase ratios of PGI2/ TXA2 , reduce extent s of arteriosclerosis. CONCLUSION:There were abnormalities of lipid peroxidate metabolism , PGI2/ TXA2 equilibrium , and anti- effect s of amlodipine , in arteriosclerotic rabbit s , which might be related to it′s anti-oxide function.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2004-6-23
更新日期/Last Update: 2004-11-01