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血小板源生长因子对离体大鼠胸主动脉血管张力的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第6期
页码:
523-525
栏目:
基础研究
出版日期:
2004-11-01

文章信息/Info

Title:
Effects of platelet-derived growth factor BB on tensile force of the thoracic aorta rings of rats
作者:
任雨笙1; 黄　佐1; 杜荣增1; 潘晓明1; 顾兴建1; 吴宗贵1; 郑昌柱2
第二军医大学长征医院心血管内科,上海200003 ; 2. 上海第七人民医院心内科,上海200137
Author(s):
REN Yu-sheng1; HUANG Zuo1; DU Rong-zeng1; PAN Xiao-ming1; GU Xing-jian1; WU Zong-gui1; ZHEN G Chang-ahu2
1. Department of Cardiology ,Changzheng Hospital , Second Military Medical University , Shanghai200003
关键词:
血小板源生长因子; 大鼠;  动脉血管环;  血管收缩;  鱼精蛋白
Keywords:
platelet-derived growth factor ;  rat ;  aorta ring ;  vasoconst riction ;  protamine
分类号:
R331
DOI:
-
文献标识码:
A
摘要:
目的:观察血小板源生长因子对主动脉血管环舒缩作用的影响。方法:采用离体灌流SD 大鼠胸主动脉血管环标本,观察不同浓度的血小板源生长因子-BB(PDGF-BB) 对大鼠胸主动脉血管环的舒缩作用的影响,并与去甲肾上腺素(NE) 作对比。结果:PDGF-BB 对大鼠胸主动脉有明显的收缩作用,阈浓度为2 ×10 - 10 mol/ L ,且呈现出一种浓度依赖关系;与NE 相比,PDGF2BB 对血管的收缩幅度低于NE ,但其收缩血管的活性高于NE。PDGF-BB 对去内皮的血管同样产生收缩作用,鱼精蛋白可抑制PDGF-BB 收缩大鼠的胸主动脉的作用。结论:PDGF-BB 对大鼠胸主动脉有明显的收缩作用,且呈现出一种浓度依赖关系,其血管收缩作用为非内皮依赖性收缩作用,鱼精蛋白可抑制PDGF-BB 收缩血管的作用。
Abstract:
AIM: To investigate the effect s of platelet-derived growth factor BB (PDGF-BB) on the tensile force of the thoracic aorta rings of rat s. METHODS : The cont ractile effect s of PDGF-BB of different concent rationson on the thoracic aorta rings of rat s were observed by using the technique of vascular perfusion in vit ro , and norepinephrine severed as the cont rol. RESULTS : PDGF-BB showed a remarkable cont ractile effect on the thoracic aorta rings of rat s in a dose-dependent manner , more potent than norepinephin at the same molar concent ration. PDGF-BB could help cont ract the thoracic aorta rings in a non-endothelium-dependent manner , and protamine could inhibit the cont ractile effect of PDGF-BB on the rat thoracic rings at high concent rations. CONCLUSION: PDGF-BB could help significantly cont ract the thoracic aorta rings of rat s in dose-dependent and non-endothelium- dependent manners , and protamine could inhibit the cont ractile effect of PDGF-BB on the rat thoracic rings.

参考文献/References

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[ 2 ] 任雨笙,陈　强,贾国良,等. 血小板衍化生长因子β受体在人冠状动脉组织中的表达[J ] . 第四军医大学学报,1998 ,19 (6) :652- 654.

[3 ] Tahara A , Yasuda M , Itagane H , et al . Plasma level of platelet-derived growth factor in normal subjects and patient with ischemia heart disease[J ] . A m Heart J , 1991 ,122 (4pt 1) :986 - 992.

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[5 ] 谢良地,吴可贵,陈达光,等. 血小板源生长因子诱导血管平滑肌细胞迁移及机制[J ] . 中国动脉硬化杂志,1998 ,6 (1) : 10 -14.

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[7 ] Weissberg PL , Witchell C , Davenport AP , et al . The endothelin peptides ET-1 , ET-2 , ET-3 and sarafatoxin s6b are rmitogenic with platelet-derived growth factor for vascular smooth muscle cells [J ] . Atherosclerosis , 1990 , 85 (2 - 3) :257 - 262.

备注/Memo

备注/Memo:
收稿日期：2004-1-12
更新日期/Last Update: 2004-11-01