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|本期目录/Table of Contents|

猪左心室内膜整体复极顺序的单相动作电位标测(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第5期
页码:
409-412
栏目:
基础研究
出版日期:
2005-10-05

文章信息/Info

Title:
Global repolarization sequence of the left ventricular endocardium: Monophasic action potential mapping in swine
作者:
梁延春1;  韩雅玲1; 王祖禄1;  YUAN Shiwen2;  Bertil Olsson2
1.沈阳军区总医院心血管内科，辽宁 沈阳 110016； 2.隆德大学医院心血管内科, 瑞典 隆德 S22185
Author(s):
LIANG Yanchun1;  HAN Yaling1;  WANG Zulu1;  YUAN Shiwen2;  BERTIL Olsson2
1.Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang, Liaoning, 110016, China； 2.Department of Cardiology, University Hospital of Lund, Lund S22185, Sweden
关键词:
单相动作电位; 复极; 激动
Keywords:
monophasic action potential;  repolarization;  activation
分类号:
R541.7+5
DOI:
-
文献标识码:
A
摘要:
目的 研究猪左心室心内膜整体复极顺序。方法 应用CARTO系统，在10只猪左心室心内膜的75±12个位点记录单相动作电位。计算每一点的局部激动时间（activation time, AT）、复极结束时间(endofrepolarization time，EORT)和单相动作电位时程(monophasic action potential duration，MAPD)，并且据此建立10套三维整体心室肌AT顺序、EORT顺序和MAPD长短顺序的标测图。结果 ①EORT顺序图显示10只猪中有9只猪的EORT顺序明确地沿袭了激动顺序。②在最早的激动区域或附近记录到最长的MAPD，而在最晚的激动区域或附近则记录到最短的MAPD。③所有标测图的MAPD与AT成负线性相关，而EORT与AT成正线性相关。结论 猪左室心内膜存在复极梯度。激动顺序是复极顺序的一个决定因素。较晚的心室激动伴随着较短的MAPD，MAPD缩短幅度相对于局部激动的变晚程度，是决定复极方向和形态的关键因素。
Abstract:
AIM To evaluate the global sequence of repolarization over the ventricular endocardium in swine. METHODS Monophasic action potentials (MAPs) were recorded from 75±12 left ventricular sites in 10 healthy pigs using the CARTO system. Local activation time (AT), end of repolarization (EOR) time and MAP duration were calculated and 3dimensional global maps of AT, EOR and MAP duration were constructed. RESULTS ① In 9 of the 10 pigs, EOR sequence clearly followed the sequence of activation as shown in EOR sequence maps. ②The longest MAPs were recorded in or near the earliest activation area, and the shortest in or near the latest activation area in all the pig maps. ③In all maps, MAP duration and AT were negatively correlated, while EOR and AT were positively correlated. CONCLUSION Repolarization gradients exist over the pig left ventricular endocardium. The activation sequence is a determinant for the repolarization sequence. The magnitude of the progressive MAP shortening with progressively later activation, relative to local AT, is a critical factor governing the direction and pattern of the EOR.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2004-12-22.
更新日期/Last Update: 2010-01-05