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冠心病患者血小板功能在精神应激后的变化(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第1期
页码:
76-78
栏目:
临床研究
出版日期:
2006-01-01

文章信息/Info

Title:
Changes of platelet function under mental stress in patients with coronary artery disease
作者:
樊民1; 黄佐1; 任雨笙1; 潘晓明1; 张玲珍2; 王咏梅1; 吴宗贵1
第二军医大学长征医院:1.心血管内科, 2.实验诊断科，上海 200003
Author(s):
FAN Min1; HUANG Zuo1; REN Yu-sheng1; PAN Xiao-ming1; ZHANG Ling-zhen2; WANG Yong-mei1; WU Zong-gui1
1. Department of Cardiology, 2.Dignostic Lab,Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
关键词:
精神应激; 血小板膜糖蛋白类; P选择素; 流式细胞术
Keywords:
mental stress;  platelet membrane glycoproteins;  Pselectin;  flow cytometry
分类号:
R331.3；R541.4
DOI:
-
文献标识码:
A
摘要:
目的 观察冠心病（CAD）患者血小板功能在精神应激前后的变化。方法 用流式细胞术测定冠状动脉造影证实的22例CAD患者精神应激（心算10 min）前、结束后即刻、休息10 min后外周血血小板膜糖蛋白ⅡbⅢa复合物的α亚单位（CD41）、P选择素（CD62p）的变化。结果 精神应激后CAD患者外周血中CD41阳性率由(75±20)％增加到(89±10)％（P<0.05）；CD62p阳性百分率由(2.5±0.9)%增加到(3.5±0.8)％（P<0.05）；休息10 min后则降至应激前水平。结论 精神应激可以激活CAD患者血小板功能。
Abstract:
AIM To assay the effects of mental stress on platelet function in patients with coronary artery disease (CAD). METHODS By flow cytometry, the expression of platelet membrane glycoproteinⅡbⅢa complex αsubunit(CD41), Pselectin(CD62p) were measured and compared before and after mental stress in 22 CAD patients. RESULTS The positive percentage of CD41(from 75±20% to 89±10％, P<0.05) and CD62p(from 2.5±0.9% to 3.5±0.8%,P<0.05) were elevated significantly right after the mental stress test and returned to the pretest levels after 10min rest. CONCLUSION Mental stress may increase platelet activation in patients with CAD.

参考文献/References

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［7］ Furman MI, Benoit SE, Barnard MR, et al. Increased platelet reactivity and circulating monocyteplatelet aggregates in patients with stable coronary artery disease［J］. J Am Coll Cardiol, 1998,31(2):352-358.

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备注/Memo

备注/Memo:
收稿日期：2004-11-20.基金项目：上海市自然科学基金项目资助(No.03ZR14029) 作者简介：樊民,主治医师，讲师，博士生 Tel：(021)63610109 73202 Email：fanmin@medmail.com.cn
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