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Title:: -

作者:: 郝广华; 牛小麟; 西安交通大学第二医院心内科，陕西西安 710004

Author(s):: -

关键词:: 过氧化物酶体增殖物激活受体γ; 心室重构 ; 罗格列酮; 吡格列酮

Keywords:: -

分类号:: R541

DOI:: -

文献标识码:: A

摘要:: 研究表明，过氧化物酶体增殖物激活受体γ（PPARγ）存在于多种动物的心血管组织内，激活PPARγ可改善胰岛素抵抗，影响动脉粥样硬化病变的发生发展，并降低血压。近年来很多研究发现PPARγ及其激动剂可以抑制心室重构，但其作用机制有待阐明。

Abstract:: -

参考文献/References

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［4］齐颖新，牛小麟，赵忠良. 高血压对大鼠心肌PPARγ表达水平的影响及其意义［J］. 生物化学与生物物理进展，2004,31（10）：941-946.

［5］周庆峰,王洪新,王怡薇, 等. 吡格列酮对高糖高胰岛素诱导的心肌细胞肥大的影响［J］. 中国药理学通报，2004，20 (7) :818-821.

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［10］Chen K, Chen J, Li DY, et al. Angiotensin II regulation of collagen type I expression in cardiac fibroblasts modulation by PPARγ ligand pioglitazone ［J］ . Hypertension, 2004，44:655-661.

［11］Chen K, Li D, Zhang XJ, et al. Anoxia reoxygenation stimulates collagen type I and MMP1 expression in cardiac fibroblasts modulation by the PPARγligand pioglitazone ［J］. J Cardiovasc Pharmacol, 2004，44:682-687.

［12］Iglarz M, Touyz RM, Viel EC,et al. Peroxisome proliferator activated receptor-α and receptor-γ activators prevent cardiac fibrosis in mineralocorticoid dependent hypertension［J］. Hypertension, 2003，42:737-743.

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过氧化物酶体增殖物激活受体γ与心室重构(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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