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|本期目录/Table of Contents|

坐位下体负压对人体心脑血管系统的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第5期
页码:
574-576,582
栏目:
临床研究
出版日期:
2006-10-25

文章信息/Info

Title:
Effects of lower body negative pressure in upright seated position on human cardiovascular system and cerebrovascular system
作者:
韩文强1; 田锐锋2; 马瑞山3
第四军医大学：1.航空航天医学装备教研室，2.校直干休所，3.航空航天生理学教研室，陕西 西安 710032
Author(s):
HAN Wen-qiang1;  TIAN Rui-feng2;  MA Rui-shan3
1.Department of Aerospace Medical Equipment，2.District Retried Cadres Entertainment Center,3.Department of Aerospace Physiology, Fourth Military Medical University, Xi’an,Shaanxi 710033, China
关键词:
下体负压; 经颅多普勒超声检查; 大脑中动脉血流速度; 阻力指数; 搏动指数
Keywords:
lower body negative pressure;  transcranial Doppler ultrasonography;  blood flow velocity in middle cerebral;  resistive index;  pulsatility index
分类号:
R852.21
DOI:
-
文献标识码:
A
摘要:
目的 探讨坐位下体负压对人体心脑血管系统的影响。方法 15名健康青年男性在-4.00 kPa、-6.67 kPa坐位下体负压下，分别测试负压前、负压暴露0.5、1、2、3、4、5 min和卸压后1、3、5 min的大脑中动脉的搏动指数（PI）、阻力指数（RI）、血流速度（VMCA），心率（HR），血氧饱和度（SaO2），血压（BP）及主观症状和客观体征。结果 在-4.00 kPa下体负压作用下，PI、RI、BP、SaO2无明显改变，VMCA在负压作用4、5 min时减慢(P<0.05)；HR在负压作用3、4、5 min时增快 (P<0.05)。在-6.67 kPa下体负压作用下，PI、RI在负压作用4、5 min时增大(P<0.05)；VMCA 在负压作用2、3 min时显著减慢(P<0.05)，在4、5 min时非常显著减慢(P<0.01), 卸压后1 min尚未恢复(P<0.05)，随后恢复至对照水平；负压作用各时间点HR均显著增快(P<0.01)；SaO2在负压暴露5 min时显著下降(P<0.05)；收缩压与负压前无明显变化，舒张压显著升高(P<0.05)。结论 坐位下体负压造成血液在下肢淤积，搏动指数和阻力指数升高，大脑中动脉血流速度减慢，引起大脑血供减少，为空中晕厥和立位耐力不良的医学鉴定提供了人体实验依据。
Abstract:
AIM To investigate the effects of lower body negative pressure (LBNP) in the upright seated position on the human cardiovascular system and cerebrovascular system. METHODS Fifteen healthy males were included as subjects. The pulsatility index (PI), resistance index (RI), blood flow velocity in middle cerebral (VMCA), pulse rate,blood oxygen saturation (SaO2） and blood pressure (BP) of middle cerebral artery with their subjective symptoms and objective physical signs were measured at 0.5, 1, 2, 3, 4 and 5 min during LBNP and 1, 3 and 5 min after -4.00 kPa and -6.67 kPa LBNP respectively in upright seated position. RESULTS Under -4.00 kPa LBNP, VMCA slowed down at 4 and 5 min during LBNP (P<0.05) and pulse rate speeded up at 3,4 and 5 min during LBNP (P<0.05). There were no significant changes of PI, RI, BP and SaO2. Under -6.67 kPa LBNP, PI and RI augmented at 4 and 5 min during LBNP (P<0.05). VMCA slowed down at 2 and 3 min during LBNP (P<0.05), and at 4 to 5 min VMCA decelerated more significantly during LBNP (P<0.01). At 1 min after the release of LBNP, VMCA did not recover (P<0.05), after which it recovered to control level. The pulse rates significantly increased during LBNP at every time point (P<0.01) and SaO2 decreased move obviously at 5 min during LBNP (P<0.01). Systolic pressure had no great change but diastolic pressure notably stepped up during LBNP (P<0.05). CONCLUSION LBNP causes blood to be silted up in lower body so that PI and RI increase while VMCA decreases, thus causing loss of brain blood volume. The results of this experiment provide some experimental data for the diagnosis of presyncope syndrome and orthostatic intolerance.

参考文献/References

［1］ 吴萍，谢宝生，黄伟芬，等. 下体负压在航空航天医学中的应用［J］. 航天医学与医学工程，2002，15（3）：223-226.

［2］ 肖一之. 坐位下体负压舱的研制［J］. 应用生理学杂志，1985，1（4）：309-311.

［3］ Yao YJ, Wu XY,Sun XQ， et al. Changes of human cerebral bottom artery hemodynamics during 21d headdown tilt(-6°) bedrest ［J］. Space Medicine & Medical Engineering, 2001, 14 (1): 11-16.

［4］Balldin UI, Krock LP, Hopper NL, et al. Cerebral artery blood flow velocity changes following rapid release of lower body negative pressure ［J］. Aviat Space Environ Med，1996, 67(1):19-22.

［5］胡志红,赵国璇,杨静生,等. 下体负压下脑血流的变化［J］. 航天医学与医学工程，1996, 9（5）：364-368.

备注/Memo

备注/Memo:
收稿日期：2005-04-11.作者简介：韩文强，硕士 Tel：（029）84774389
更新日期/Last Update: