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|本期目录/Table of Contents|

乌拉坦麻醉深度与家兔心脏自主神经功能的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第6期
页码:
626-628，635
栏目:
基础研究
出版日期:
2006-12-25

文章信息/Info

Title:
Relationship between urethane anesthesia depth and cardiac autonomic nervous function in rabbits
作者:
张引国1; 魏洁2
1.武警医学院病理生理学教研室,天津 300162; 2.天津市公安局安康医院精神科,天津 300240
Author(s):
ZHANG Yin-guo1;  WEI Jie1
1.Department of Pathophysiology, Medical College of Chinese People′s Armed Police Forces, Tianjin 300162, China； 2.Department of Psychiatry, Ankang Hospital, Tianjin Public Security Bureau, Tianjin 300240, China
关键词:
麻醉深度; 乌拉坦; 心率变异性
Keywords:
depth of anesthesia;  urethane;  heart rate variability
分类号:
R540.4
DOI:
-
文献标识码:
A
摘要:
目的 观察乌拉坦不同麻醉深度下家兔心脏自主神经功能的变化特征。方法 应用心率变异性(HRV)分析确定静脉注射不同累积剂量乌拉坦(0.50、1.00、1.25、1.50、1.75、 2.00、2.25、 2.50 g/kg)对家兔自主神经的张力及均衡性的影响。结果 时域成分：与剂量0.50 g/kg相比，心率在累积剂量1.25、1.50和1.75 g/kg时加快（P<0.05），R-R间期在相应的3个剂量减小（P<0.05）；正常R-R间期的标准差在累积剂量1.00 g/kg之后减小（P<0.05或P<0.01），R-R间期总变异在累积剂量1.25 g/kg之后减小（P<0.05或P<0.01）。频域成分：与剂量0.50 g/kg相比，低频功率在累积剂量1.25、1.50、2.00、2.25和 2.50 g/kg减小（各P<0.05），但归一化低频功率无变化；高频功率(HF)在各累积剂量间无变化，但归一化高频功率在累积剂量1.25 g/kg之后均增大（P<0.05）；LF/HF在累积剂量1.00 g/kg之后显著减小（P<0.01）。结论 乌拉坦麻醉过程中，家兔HRV降低的主要原因是心脏迷走副交感神经活性增加。
Abstract:
AIM To observe the dynamic changes of cardiac autonomic nervous function in rabbits under different depth of urethane anesthesia. METHODS An analysis of heart rate variability (HRV) was used to quantify the influence on the drive of cardiac autonomic nerves and the balance control of heart rate in rabbits with urethane anesthesia of different accumulated doses (0.50, 1.00, 1.25, 1.50, 1.75, 2.00, 2.25 and 2.50 g/kg). RESULTS The time domain components: Compared with heart rate (HR) at dose 0.50 g/kg, the HR increased at doses 1.25, 1.50 and 1.75 g/kg (P<0.05 ) and there was a corresponding decrease in RR interval (RRI). The value of the standard deviation of all normal RR intervals (SD) decreased at doses higher than 1.00 g/kg（P<0.05 or P<0.01） and the total power variability of HR (TV) decreased at doses higher than 1.25 g/kg（P<0.05 or P<0.01. The frequency domain components: Compared with the value of low frequency power (LF) at dose 0.50 g/kg, the value of LF decreased at doses 1.25, 1.50, 2.00, 2.25 and 2.50 g/kg（P<0.05, respectively）but there were no significant changes in the value of the normalized low frequency power (LFn) at other doses. The value of high frequency power (HF) showed no significant changes at all the accumulated doses but the normalized high frequency power (HFn) increased markedly (P<0.05 ) at doses higher than 1.25 g/kg. The ratio of low to high frequency power (LF/HF) decreased significantly (P<0.01) at accumulated doses higher than 1.00 g/kg. CONCLUSION HRV decreases in rabbits under different accumulated urethane anesthesia may come from the significant increase in cardiac vagal nerve activity.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2006-01-06.作者简介：张引国,副教授,硕士 Tel:(022)60578250 Email:yinguozh@sohu.com
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