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|本期目录/Table of Contents|

福辛普利和美托洛尔对心力衰竭患者血浆细胞因子及心脏功能的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第6期
页码:
650-652
栏目:
临床研究
出版日期:
2006-12-25

文章信息/Info

Title:
Effect of fosinopril and metoprolol on plasma levels of cytokines and cardiac function in heart failure patients
作者:
梅霞1; 郑向清1; 田颖2; 李振魁3; 罗羽慧1; 王江2; 祝善俊2
1.重庆中山医院心内科，重庆 400013；2.第三军医大学新桥医院心内科，重庆 400037；3.兰州军区总医院心内科，甘肃 兰州 730070
Author(s):
MEI Xia;  ZHENG Xiang-qing;  TIAN Ying;  LI Zhen-kui;  LUO Yu-hui;  WANG Jiang;  ZHU Shan-jun
Department of Cardiology, Zhongshan Hospital, Chongqing 400013, China
关键词:
心力衰竭; 福辛普利; 美托洛尔; 细胞因子
Keywords:
heart failure; fosinopril; metoprolol; cytokine
分类号:
R541.6
DOI:
-
文献标识码:
A
摘要:
目的 探讨单独或联合应用美托洛尔和福辛普利对心衰患者血浆细胞因子及心功能的影响。方法 将80例心力衰竭患者随机分为福辛普利组、美托洛尔组和联合用药组，分别在入院和治疗后12个月时检测外周血细胞因子、心功能分级和心胸比率。结果 治疗12个月后除福辛普利组TNFα无明显变化外，其余均有所降低。福辛普利组与美托洛尔组各项指标间无明显差异，而联合用药组相对于另外两组比较血浆3种细胞因子水平均显著降低（P<0.01）。3组心功能分级均显著改善（P<0.01），联合用药组比其他两组更加明显；美托洛尔组和联合用药组心率和心胸比率均显著减小（P<0.05或P<0.01），福辛普利组则无明显变化。结论 美托洛尔和福辛普利能改善心衰患者血浆细胞因子水平及心功能，合用时效果更好。
Abstract:
AIM To explore the effect of fosinopril and metoprolol on the plasma levels of cytokines and cardiac function in patients with congestive heart failure (CHF). METHODS Eighty patients with CHF were divided into three groups: fosinopril group, metoprolol group and combination group. The plasma levels of cytokines, NYHA class and Groedel Index were detected at baseline and 12 months after the treatment. RESULTS After 12month treatment, the plasma levels of cytokines decreased significantly in all groups except TNFα in fosinopril group. There was no significant difference between fosinopril and metoprolol groups, but those in combination group decreased remarkably (all, P<0.01) compared with those in the other two groups. NYHA class improved in all groups, especially in combination group. The heart rate and Groedel Index in metoprolol group and combination group decreased obviously while no such decrease was found in fosinopril group. CONCLUSION Fosinopril and metoprolol can improve the cardiac function and the plasma level of cytokines.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2005-05-18.基金项目：重庆市医学科研资金资助项目（No.032127） 通讯作者：祝善俊,主任医师，主要从事心力衰竭的诊断与治疗方面研究 Tel:(023)68755701 作者简介：梅霞，主任医师 Tel:(023)63534527 Email: luoyuluoyu@sohu.com
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