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|本期目录/Table of Contents|

短期房颤对兔肺静脉心肌细胞有效不应期及L型钙电流的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第2期
页码:
143-145/150
栏目:
基础研究
出版日期:
2007-04-01

文章信息/Info

Title:
Effects of shortterm atrial fibrillation on effective refractory period and Ltype calcium current of rabbit pulmonary vein cardiomyocytes
作者:
刘军1; 毕辉2; 朱妙章2; 郑强荪1; 卢少平1
第四军医大学：1.唐都医院心脏内科，陕西 西安 710038,2.基础部生理学教研室，陕西 西安 710032
Author(s):
LIU Jun;  BI Hui;  ZHU Miaozhang;  ZHENG Qiangsun;  LU Shaoping
Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi′an 710038, Shaanxi, China
关键词:
肺静脉源性; 房颤; 有效不应期; L型钙电流; 电重构
Keywords:
pulmonary vein source;  atrial fibrillation;  effective refractory period;  Ltype calcium current;  electrical remodeling
分类号:
R541.75
DOI:
-
文献标识码:
A
摘要:
目的 研究在短期快速肺静脉起搏下，易诱发房颤(AF)的兔肺静脉心肌细胞有无急性电重构改变。方法 建立兔肺静脉源性AF的动物模型，应用程序刺激的方法测定和计算肺静脉远、近两端的有效不应期之差（ΔERP）；并通过全细胞膜片钳技术记录钙离子流变化。结果 在同样刺激条件下，不是所有实验动物均可诱发出AF。快速肺静脉起搏和AF时均引起肺静脉远、近两端心肌细胞ERP之差值（ΔERP）减小，同时在AF持续过程中还可引起钙电流减小。结论 通过短期快速肺静脉刺激，发现易触发AF的肺静脉在AF发生和持续时，其肺静脉心肌细胞有急性电重构的存在，L型钙电流减小可能是短期AF导致肺静脉心肌细胞发生急性电重构的离子基础之一。
Abstract:
AIM To study whether acute electrophysiological remodeling occurred in pulmonary vein cardiomyocytes during easilyinduced atrial fibrillation (AF) caused by shortterm rapid pacing of pulmonary vein. METHODS Rabbit models of pulmonary vein atrial fibrillation were established. The differences of effective refractory period (ΔERP) between distal and proximal part of pulmonary vein were determined and calculated by program stimulation and the changes of ionic calcium current was recorded by whole-cell patch clamp technique. RESULTS Under the same stimulus, atrial fibrillation was not induced in all the experimental animals. The shortterm rapid pacing of pulmonary vein and atrial fibrillation resulted in the decrease of ΔERP difference between distal and proximal part of pulmonary vein. With the maintenance of AF, Ltype calcium current (ICa·L) reduced in pulmonary vein cardiomyocytes. CONCLUSION Acute electrophysiological remodeling has been detected in pulmonary vein cardiomyocytes of easilyinduced AF during initiation and maintenance of AF caused by shortterm rapid pacing of pulmonary vein. The decrease of ICa·L may contribute to ionic basis of acute electrical remodeling of pulmonary vein cardiomyocytes caused by shortterm AF.

参考文献/References

［1］ Niwano S.The atrial electrical remodeling in atrial fibrillation［J］. Nippon Rinsho, 2002,60(7):1308-1316.

［2］ Li Y, Li WM, Xue JY, et al. Effects of Losartan on acute atrial electrical remodeling［J］. Chin Med J (Engl), 2004, 117(5):643-646.

［3］ Kurita Y, Mitamura H, ShiroshitaTakeshita A, et al. Daily oral Verapamil before but not after rapid atrial excitation prevents electrical remodeling［J］. Cardiovasc Res, 2002, 54(2):447-455.

［4］ Hadian D, Zipes DP, Olgin JE, et al. Shortterm rapid atrial pacing produces electrical remodeling of sinus node function in humans［J］. J Cardiovasc Electrophysiol, 2002 , 13(6):584-586.

［5］ 杨玉辉，郑强荪，董建军, 等. 消融犬右肺静脉脂肪垫对心房及右上肺静脉电生理特性及AF诱发的影响［J］. 心脏杂志，2006，18（1）：28-30.

［6］ Fynn SP, Kalman JM. Pulmonary veins: anatomy, electrophysiology, tachycardia, and fibrillation［J］. Pacing Clin Electrophysiol, 2004, 27(11): 1547-1559.

［7］ Khan R. Identifying and understanding the role of pulmonary vein activity in atrial fibrillation［J］. Cardiovasc Res, 2004, 64(3): 387-394.

［8］ Herweg B, Sichrovsky T, Polosajian L, et al. Anatomic substrate, procedural results, and clinical outcome of ultrasoundguided left atrialpulmonary vein disconnection for treatment of atrial fibrillation［J］. Am J Cardiol, 2005, 95(7):871-875.

备注/Memo

备注/Memo:
收稿日期：2006-10-30.基金项目：全军医学科研“十五”计划项目资助(No. 01MB126)通讯作者：朱妙章，教授，主要从事心血管生理的基础研究Email:mz_zhu@fmmu.edu.cn作者简介：刘军，主治医师，博士生Email：jl9212003@yahoo.com.cn
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