我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

自主神经系统对在体兔急性心肌梗死跨室壁有效不应期离散度的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第2期
页码:
151-153/162
栏目:
基础研究
出版日期:
2007-04-01

文章信息/Info

Title:
Effect of autonomic nervous system on transmural dispersion of effective refractory period upon acute myocardial infarction in rabbits in vivo
作者:
雷靖祎; 郑强荪; 高渊; 张超 ; 刘雄涛; 杨玉辉; 张中; 张宪伟; 刘文秀
第四军医大学唐都医院心内科，陕西 西安 710038
Author(s):
LEI Jingyi;  ZHENG Qiangsun;  GAO Yuan;  ZHANG Chao;  LIU Xiongtao;  YANG Yuhui;  ZHANG Zhong;  ZHANG Xianwei;  LIU Wenxiu
Department of Cardiology, Tangdu Hospital,Fourth Military Medical University, Xi′an 710038, Shaanxi, China
关键词:
自主神经系统; 有效不应期; 心肌梗塞; 急性; 不应期离散度; 家兔
Keywords:
autonomic nervous system;  effective refractory period;  myocardial infraction; acute;  transmural dispersion of effective refractory period;  rabbit
分类号:
R331.3
DOI:
-
文献标识码:
A
摘要:
目的 为探讨自主神经系统对在体家兔急性心肌梗死（AMI）后跨室壁3层心肌细胞有效不应期（ERP）离散度的影响。 方法 分别在基础和心肌梗死状态下,在交感神经和迷走神经刺激的过程中,用自制复合电极结合程序电刺激法测定家兔在体基础和梗死时心外膜心肌、中层心肌和心内膜心肌的ERP，并计算跨室壁ERP的离散度（TDERP）。结果 在基础状态下,交感神经刺激能缩短3层心肌细胞的ERP,中层心肌细胞的ERP缩短最明显,TDERP由(21±17)ms 增加到(30±16)ms (P<0.05);迷走神经刺激能延长3层心肌的ERP,心内膜心肌ERP增加明显,TDERP由(21±17)ms 降低到(24±18)ms,差异无显著性 。在AMI后30 min,交感神经刺激延长3层心肌细胞的ERP,其中中层心肌细胞的ERP增加最明显,与基础状态下交感刺激相比,TDERP由(30±16)ms 增加到(38±11)ms ( P<0.05) ;迷走神经刺激时TDERP为(21±13)ms,与基础状态(24±18)ms迷走刺激相比,TDERP无显著变化。结论 AMI后,交感神经兴奋能增加TDERP;迷走神经兴奋对TDERP无显著影响。
Abstract:
AIM To investigate the effect of autonomic nerves on the transmural dispersion of effective refarctory period (TDERP) upon acute myocardium infarction (AMI) in vivo. METHODS Using programmed stimulation method, the effective refractory periods（ERP） of epicardium (Epi), midmyocardium (Mid) and endocardium (Endo) were measured during sympathetic and parasympathetic stimulation before AMI and 30 minutes after AMI in 20 open chest rabbits. RESULTS The ERP of Epi, Mid and Endo were shortened during sympathetic stimulation under normal condition, but the ERP of the Mid was shortened more significantly than that of Epi or Endo and TDERP increased from (21±17)ms to (30±16)ms( P<0.05). The ERPs of Epi, Mid and Endo were prolonged during sympathetic stimulation under acute myocardial infraction, the ERP of the Mid was prolonged more than that of Epi or Endo and TDERP decreased from (21±17)ms to (24±18)ms ( P<0.05). The ERPs of Epi, Mid and Endo were prolonged during parasympathetic stimulation under normal condition, the ERP of the Endo was prolonged more significantly than that of Epi or Mid, and TDERP increased from (30±16)ms to (38±11)ms (P<0.05). The ERPs of Epi, Mid and Endo were not significantly affected during parasympathetic stimulation under AMI and TDERP was not significantly different between the two groups. CONCLUSION Sympathetic stimulation increases TDERP under normal condition and under AMI. Parasympathetic stimulation does not significantly affect TDERP.

参考文献/References

［1］方昶, 张旭明, 伍卫，等.哌仑西平对兔急性心肌缺血心室颤动阈值的影响及其机制［J］.心脏杂志，2002，14（3）：204-207.

［2］Issa ZF, Zhou XH, Ujhelyi MR,et al .Thoracic Spinal Cord Stimulation Reduces the Risk of Ischemic Ventricular Arrhythmias in a Postinfarction Heart Failure Canine Model ［J］. Circulation, 2005,111(24): 3217 - 3220.

［3］杨天骄，马业新，肖建民，等.犬在体心肌跨室壁复极不均一性的研究［J］.中华心血管病杂志，2002，30(4)：239-241.

［4］臧益民，臧伟进. M细胞，跨室壁离散度与心律失常的关系［J］. 心脏杂志，2002，14（5）：343-345.

［5］姚青海,崔长琮,李强,等. 单相动作电位同步记录电极的建立和应用［J］. 西安交通大学学报(医学版), 2005，26 (1) ：89-92.

［6］Burton FL,Cobbe SM. Transmural dispersion of repolarization and refractory period［J］. Cardiovasc Res,2001,50 (1) :10-23.

［7］Elvan A,Zipes DP. Right ventricular infarction causes heterogeneous autonomic denervation of the viable periinfarct area ［J］. Circulation, 1998,97 (5):484-492.

［8］吕家高，张繁之，王琳，等.急性缺血时犬3 层心肌单向动作电位时程和有效ERP变化［J］.临床心血管病杂志，2005,21(11): 660-662.

［9］Bauer A,Becker R,Freigang KD,et al . Rate and Site-Dependent effects of propafenone, dofetilide, and the new IKsBlocking agent chromanol 293b on individual muscle layers of the intact canine heart ［J］ . Circulation, 1999,100(21) : 2184-2190.

［10］赵庆彦，黄从新，杨波，等. 阻断迷走神经对心房肌有效不应期及其离散的影响［J］ . 中国心脏起搏与心电生理杂志，2003，17（1）：57-59.

［11］Lampert R, Joska T, Burg MM,et al. Emotional and Physical Precipitants of Ventricular Arrhythmia［J］ . Circulation，2002,106(14)：1800-1805.

［12］Chiou CW, Chen SA, Kung MH,et al . Effects of Continuous Enhanced Vagal Tone on Dual Atrioventricular Node and Accessory Pathways［J］ .Circulation, 2003,107(20)：2583-2588.

备注/Memo

备注/Memo:
收稿日期：2006-07-05.通讯作者：郑强荪，教授，主要研究方向心脏起搏与电生理Email:qingshu@fmmu.edu.cn 作者简介：雷靖祎，主治医生，硕士生Email：leijingy@fmmu.edu.cn
更新日期/Last Update: