卡托普利治疗稳定劳力型心绞痛的临床效果(PDF)
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2007年第2期
- 页码:
- 200-201/204
- 栏目:
- 临床研究
- 出版日期:
- 2007-04-01
文章信息/Info
- Title:
- Clinical observation of captopril in 265 patients with stable effort angina pectoris
- Author(s):
- ZHAO Yue; WANG Rongjun; ZHAO Ruige
- Department of Cardiology, Fuxin Central Hospital, Fuxin 123000, Liaoning,China
- Keywords:
- coronary disease; captopril; heart rate; systolic blood pressure; diastolic blood pressure
- 分类号:
- R541.6
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的 观察卡托普利在稳定劳力型心绞痛治疗中的作用。方法 选择稳定劳力型心绞痛患者265例，将其随机分为常规治疗组（阿司匹林、β受体阻滞剂、钙拮抗剂、硝酸酯类）129例，年龄（57±111）岁，卡托普利组（常规治疗基础上加卡托普利12.5 mg，3次/d）136例，年龄（58±10）岁。观察治疗24周时两组患者心绞痛分级，测量心率、血压，计算心率×收缩压值；并做运动心电图，观察运动中诱发心绞痛时间（s）、ST段下移≥0.1 mV时或心绞痛发作时的心率、ST段下移最大程度（mV）及ST段下移持续最长时间（s）。结果 两组治疗24周后心绞痛分级均明显改善，卡托普利组较常规治疗组心率显著减慢， SBP、DBP及心率×收缩压值显著降低，运动中诱发心绞痛的时间延长，ST段下移≥0.1 mV或心绞痛发作时心率增加，ST段下移持续最长时间缩短。结论 卡托普利治疗劳力型心绞痛患者能减轻心绞痛症状，增加运动耐量。
- Abstract:
- AIM To observe the effects of captopril on patients with stable effort angina pectoris. METHODS Two hundred and sixtyfive patients with stable effort angina were included in our study and the patients were randomized into two groups. Patients in group without captopril［129 patients ages （57±11） years］ received aspirin, nitrates, betablocker and calciumantagonist and patients in group with captopril ［136 patients ages（58±10）years］received conventional treatment plus captopril (12.5 mg three daily). After 24 weeks' treatment, stable functional class angina, heart rate (HR), blood pressure (BP) and the ratepressure product (mean of three times) were measured. A Bruce stress test was conducted after conventional treatment with captopril. The time to exerciseinduced angina, the HR to onset of ST segment depression ≥1 mm or angina appears, peak ST segment depression, and the maximal lasting time to onset of ST depression were observed. RESULTS Captopril significantly improved the stable functional class angina, resulted in a significantly reduced heart rate, the systolic and diastolic blood pressures, and the ratepressure product (P<0.01). The captopril group delayed the occurrence time of exerciseinduced anginal symptoms (P<0.01), increased the heart rate angina attacks or ST segment depression ≥1 mm (P<0.05) and reduced the lasting time ST depression in captopril group compared with those in no captopril group. CONCLUSION Captopril can effectively treat patients with stable effort angina and can significantly alleviate clinical symptoms and enhance exercise tolerance.
参考文献/References
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［2］ Vaughan DE. Angiotensin,fibrinolysis, and vascular homeostasis ［J］. Am J Cardiol, 2001,87(8A):18C-24C.
［3］ Scheidegger KJ, Butler S, Witztum JL. Angiotensin II increases macrophagemediated modification of low density lipoprotein via a lipoxygenasedependent pathway ［J］. J Biol chem, 1997, 272 (12): 21609-21615.
［4］ 王建春, 王曙霞, 邵建华. 一氧化氮与心肌缺血预适应［J］. 心血管病学进展, 2003, 24 (4): 291-293.
［5］ 贾如意, 岳文伟, 孙海玲. 卡托普利对心绞痛患者流变学和心肌缺血的影响［J］. 心脏杂志，2004, 16 (4): 346-348.
备注/Memo
- 备注/Memo:
- 收稿日期：2006-02-17.作者简介：赵月，主任医师Email：xb1962@21.cn
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