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甲状腺功能亢进大鼠基底动脉与肠系膜小动脉血管反应性的变化(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第4期
页码:
416-420
栏目:
基础研究
出版日期:
2007-08-01

文章信息/Info

Title:
Alterations in arterial reactivity of basilar artery and small mesenteric artery in hyperthyroid rats
作者:
张誉洋1; 王海昌1; 张然1; 王云英2; 暴军香2; 汤浩2; 白云刚2; 马进2
第四军医大学：1.西京医院心脏内科，2.航空航天生理学教研室，陕西 西安 710032
Author(s):
ZHANG Yuyang1;  WANG Haichang1;  ZHANG Ran1;  WANG Yunying2;  BAO Junxiang2;  TANG Hao2;  BAI Yungang2;  MA Jin2
1.Department of Cardiology, Xijing Hospital， 2.Department of Aerospace Physiology, School of Aviation and Aerospace Medicine, Fourth Military Medical University, Xi′an 710032, Shaanxi, China
关键词:
甲状腺功能亢进; 左旋甲状腺素; 动脉反应性; 大鼠
Keywords:
hyperthyroidism;  Lthyroxine;  arterial responsiveness;  rat
分类号:
R581.1
DOI:
-
文献标识码:
A
摘要:
目的 观察甲状腺功能亢进大鼠大脑基底动脉及肠系膜小动脉血管反应性的变化，深入探讨甲亢对动脉血管系统功能的影响。方法 体质量350 g左右的16只雄性SD大鼠，随机分为对照组与甲亢组，采用左旋甲状腺素（左旋T4，优甲乐）0.6 mg/(kg.d)给大鼠灌胃25 d，建立甲亢大鼠模型。利用离体动脉环测定大脑基底动脉、肠系膜小动脉血管的反应性。结果 甲亢组与对照组相比，基底动脉及肠系膜小动脉对氯化钾（10～100 mmol/L）与苯肾上腺素(10-9～10-4 mol/L)引起的收缩反应均显著减弱（P<0.05）；对乙酰胆碱(10-9～10-4 mol/L)引起的舒张反应均显著增强（P<0.05）；对硝普钠(10-9～10-4 mol/L)引起的舒张反应均无明显变化。甲亢组大鼠基底动脉及肠系膜小动脉对氯化钾和乙酰胆碱反应的敏感性增强（P<0.05），对苯肾上腺素和硝普钠反应的敏感性无明显差别。结论 甲状腺功能亢进大鼠基底动脉及肠系膜小动脉收缩反应性降低，而内皮介导的舒张反应性增强。
Abstract:
AIM To determine the alterations in arterial reactivity of basilar arteries and small mesenteric arteries in rat models under hyperthyroidism established by Euthyrox containing LT4. METHODS Sixteen male SD rats of body weight about 350g were randomly divided into the hyperthyroid group (n=8) and the control group (n=8). After 25 days' administration of Euthyrox in the hyperthyroid group, arterial rings from basilar arteries and small mesenteric arteries of rats were isolated and effects of hyperthyroidism on arterial responsiveness were examined in vitro. RSEULTS The isometric contractile tensions evoked by KCl（10～100 mmol/L）and phenylephrine (PE) (10-9～104 mol/L) were significantly lower in basilar and mesenteric branch arterial rings from hyperthyroid rats compared with those of controls (P<0.05). The vasodilator response induced by acetylcholine (ACh) (10-9～10-4 mol/L) significantly increased in the hyperthyroid group (P<0.05). But the differences of dilatory responses of those arterial rings induced by sodium nitroprusside (SNP) (10-9 ～10-4 mol/L) between the two groups were not significant. The sensitivities of those arterial rings to KCl and ACh were significantly enhanced by hyperthyroid (P<0.05), whereas the sensitivity to PE and SNP did not show any significant differences between the two groups. CONCLUSION Hyperthyroidism may result in depressed ability of smooth muscles to develop tension and increased endotheliumdependent vasorelaxation in basilar arteries and small mesenteric arteries.

参考文献/References

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［9］ 马进,任新玲,程九华,等. 模拟失重大鼠去内皮股动脉血管反应性的变化［J］. 中华航空航天医学杂志, 2003,14(4):200-203.

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备注/Memo

备注/Memo:
收稿日期：2006-12-20.基金项目：第四军医大学后备人才基金项目资助（No.4138A4307）通讯作者：马进，副教授，主要从事心血管生理学研究Email：jin-ma@fmmu.edu.cn 作者简介：张誉洋，医师，硕士生Email：zyy97168@sina.com
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