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高血糖对2型糖尿病患者胰岛β细胞功能的抑制作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第5期
页码:
553-555
栏目:
临床研究
出版日期:
2007-10-01

文章信息/Info

Title:
Inhibitive effect of hyperglycemia on pancreatic βcell secretion in type 2 diabetic patients
作者:
苏慧1; 孙新2; 王晓明1; 陈金凤1; 房海英1; 徐先桔1; 黄晨1
第四军医大学西京医院：1.老年病二科，2.小儿科，陕西 西安 710032
Author(s):
SU Hui1;  SUN Xin2;  WANG Xiaoming1;  CHEN Jinfeng1;  FANG Haiying1;  XU Xianju1;  HUANG Chen1
1.Second Department of Geriatrics, 2.Department of Pediatrics, Xijing Hospital, Fourth Military Medical University, Xi′an 710032, Shaanxi, China
关键词:
糖尿病; 2 型; 高血糖
Keywords:
diabetes mellitus;  type 2; hyperglycemia
分类号:
R587.1
DOI:
-
文献标识码:
A
摘要:
目的 了解高血糖状态对2型糖尿病患者胰岛β细胞分泌功能的影响。方法 应用口服葡萄糖耐量试验(OGTT)观察28 例新发2型糖尿病( T2DM) 患者在前后不同血糖状态下的胰岛β细胞的分泌功能。结果 胰岛素和C肽释放倍数随空腹血糖的下降而升高( P<0.05)；胰岛β细胞功能指数(HOMAβ)与空腹血糖水平呈负相关( P<0.01) 。结论 空腹高血糖可抑制胰岛β细胞的分泌功能，短期降糖治疗后胰岛β细胞功能可显著改善。
Abstract:
AIM To study the effects of hyperglycemia on the pancreatic βcell secretion in type 2 diabetic patients. METHODS We investigatedthe pancreatic βcell secretion response to stimulation of standard oral glucose at different blood glucose levels in 28 patients with newdiagnosed type 2 diabetes. RESULTS The releases of insulin and Cpeptide increased with the decreased levels of fasting blood glucose (P<0.05). There was a negative association between the HOMAβ index and fasting blood glucose (P<0.01). CONCLUSION The pancreatic βcellsecretion is inhibited by fasting hyperglycemia and is improved after the control of hyperglycemia.

参考文献/References

［1］Kaneto H, Nakatani Y, Kawamori D, et al. Role of oxidative stress, endoplasmic reticulum stress, and cJun Nterminal kinase in pancreatic betacell dysfunction and insulin resistance［J］. Int J Biochem Cell Biol,2006,38(56):782-793.

［2］王凌燕,蔡高军. 餐后高血糖对心血管系统的影响［J］.心脏杂志，2006,18(3):359-361.

［3］Krauss S, Zhang CY, Scorrano L, et al. Superoxidemediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction［J］. J Clin Invest,2003,112(12):1831-1842.

［4］Robertson RP, Harmon J, Tran PO, et al. Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes［J］. Diabetes,2004,53 Suppl 1:S119-S124.

［5］Boden G, Ruiz J, Kim CJ, et al. Effects of prolonged glucose infusion on insulin secretion, clearance, and action in normal subjects［J］. Am J Physiol,1996,270(2 Pt 1): E251-E258.

［6］Maedler K, Sergeev P, Ris F, et al. Glucoseinduced beta cell production of IL1beta contributes to glucotoxicity in human pancreatic islets［J］. J Clin Invest,2002,110(6):851-860.

［7］Marshak S, Leibowitz G, Bertuzzi F, et al. Impaired betacell functions induced by chronic exposure of cultured human pancreatic islets to high glucose［J］. Diabetes,1999,48(6):1230-1236.

备注/Memo

备注/Memo:
收稿日期：2006-11-22.通讯作者：黄晨，教授，主要从事2型糖尿病的诊断和治疗研究Email:xjhbzr@fmmu.edu.cn作者简介：苏慧，主治医师，博士Email:huisu5016@yahoo.com.cn
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