文章摘要

文章信息/Info

Title:: -

作者:: 周健综述; 黄岚审校; 第三军医大学附属新桥医院全军心血管内科中心，重庆 400037

Author(s):: -

关键词:: 环氧化酶; 环氧化酶抑制剂; 血管生成; 高血压; 动脉硬化

Keywords:: -

分类号:: R541

DOI:: -

文献标识码:: A

摘要:: 环氧化酶抑制剂阿司匹林是缺血性心脑血管疾病治疗的基础药物，但最近发现选择性环氧化酶2抑制剂对心血管系统产生多种不良作用，环氧化酶与心血管系统关系密切。本文就最近几年有关环氧化酶，环氧化酶抑制剂在心血管方面的作用，包括对血管生成、血管再狭窄、血压，心脏功能，血栓形成及动脉硬化等方面的作用进行综述。

Abstract:: -

参考文献/References

［1］ Castro MR, Lutz D, Edelman JL, et al. Effect of COX inhibitors on VEGFinduced retinal vascular leakage and experimental corneal and choroidal neovascularization［J］. Exp Eye Res, 2004, 79(2): 275-285.

［2］ Fischer JW, Hawkiks S, Clowes AW. Pharmacologic inhibition of nitric oxide synthases and cyclooxygenases enhances intimal hyperplasia in ballooninjured rat carotid arteries［J］. J Vasc Surg, 2004,40(1): 115-122.

［3］ Kearney D, Byrne A, Crean P, et al. Optimal suppression of thromboxane A(2) formation by aspirin during percutaneous transluminal coronary angioplasty: no additional effect of a selective cyclooxygenase2 inhibitor［J］. J Am Coll Cardiol, 2004, 43(4): 526-531.

［4］ Liu Q, Chen ZQ, Bobustuc GC, et al. Local Gene Transduction of Cyclooxygenase1 Increases Blood Flow in Injured Atherosclerotic Rabbit Arteries［J］. Circulation, 2005, 111(14): 1833-1840.

［5］ Monakier D, Mates M, Kluttein M W, et al. Rofecoxib, a COX2 inhibitor, lowers Creactive protein and interleukin6 levels in patients with acute coronary syndromes［J］. Chest, 2004,125(5): 1610-1615.

［6］ Abbate A, Santini D, Biondi ZG，et al. Cyclooxygenase2 (COX2) expression at the site of recent myocardial infarction: friend or foe? ［J］.Heart, 2004 , 90(4): 440-443.

［7］李波，杨欣国，冷立娟.环氧化酶抑制剂干预心肌缺血损伤的实验研究［J］.心脏杂志,2004,16（2）:113-115.

［8］ Buerkle MA, Lehrer S, Sohn HY, et al. Selective Inhibition of cyclooxygenase2 enhances platelet adhesion in hamster arterioles in vivo［J］. Circulation, 2004, 110(14):2053-2059.

［9］ Hernandez MR, Tonda R, Pino M, et al. Evaluation of effects of rofecoxib on platelet function in an in vitro model of thrombosis with circulating human blood［J］. Eur J Clin Invest, 2004, 34(4): 297-302.

［10］Aw TJ, Haas SJ, Liew D, et al. Metaanalysis of cyclooxygenase2 inhibitors and their effects on blood pressure［J］. Arch Intern Med, 2005, 165(5): 490 -496.

［11］Sowers JR, White WB, Pitt B, et al. The effects of cyclooxygenase2 inhibitors and nonsteroidal antiinflammatory therapy on 24hour blood pressure in patients with hypertension, osteoarthritis, and type 2 diabetes mellitus［J］. Arch Intern Med, 2005, 165(2): 161- 168.

［12］Delgado RM, Nawar MA, Zewail AM,et al. Cyclooxygenase2 inhibitor treatment improves left ventricular function and mortality in a murine model of doxorubicininduced heart failure［J］. Circulation, 2004,109(11): 1428-1433.

［13］Lapointe MC, Mendez M, Leung A,et al. Inhibition of cyclooxygenase2 improves cardiac function after myocardial infarction in the mouse［J］. Am J Physiol Heart Circ Physiol, 2004,286(4): H1416-H1424.

［14］Brinker A, Goldkind L, Bonnel R, et al.Spontaneous reports of hypertension leading to hospitalisation in association with rofecoxib, celecoxib, nabumetone and oxaprozin［J］. Drugs Aging, 2004, 21(7): 479-484.

［15］Izhar M, Alausa T, Folker A，et al. Effects of COX inhibition on blood pressure and kidney function in ACE inhibitortreated blacks and Hispanics［J］. Hypertension, 2004,43(3): 573-577.

［16］Egan KM, Lawson JA, Fries S, et al. COX2derived prostacyclin confers atheroprotection on female mice［J］. Science, 2004, 306(5703): 1954–1957.

我们的网站为什么显示成这样？

环氧化酶、环氧化酶抑制剂与心血管疾病(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

文章信息/Info

参考文献/References

备注/Memo

常用功能

导航/Navigate

工具/Tools

统计/Statistics