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急性冠脉综合征患者PCI术后外周血MMP-9水平的连续观察及其临床意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第1期
页码:
58-60
栏目:
临床研究
出版日期:
2008-01-20

文章信息/Info

Title:
Continuous observation and implication of MMP-9 in peripheral blood in patients with acute coronary syndromes after PCI
作者:
殷忠; 李兰荪; 栾荣华; 张荣庆; 刘安恒; 王海昌
第四军医大学西京医院心血管内科，陕西 西安 710032
Author(s):
YIN Zhong;  LI Lansun;  LUAN Ronghua;  ZHANG Rongqing;  LIU Anheng;  WANG Haichang
Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi′an 710032, Shaanxi, China
关键词:
急性冠脉综合征; 心肌梗死; 急性; 不稳定型心绞痛; 基质金属蛋白酶-9
Keywords:
acute coronary syndromes; myocardial infarction ; acute; unstable angina; stable angina; matrix metalloprotease-9
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 观察急性冠脉综合征（ACS）患者经皮冠脉介入（PCI）术后外周血中基质金属蛋白酶-9（matrix metalloproteases-9，MMP-9）水平的连续变化，探讨MMP-9与ACS的关联性。方法 选取ACS患者39例，采用双抗体夹心ELISA测定血清MMP-9的水平。结果 ACS患者入院即刻血浆MMP-9水平显著高于对照组及稳定型心绞痛组［（66±16) vs (24±11)μg/L，P<0.01；(66±16) vs (33±11) μg/L，P<0.01］。稳定型心绞痛患者入院即刻血浆MMP-9水平显著高于对照组（P<0.01)。ACS患者PCI术后即刻，外周血MMP-9水平均较入院时显著升高（P<0.01），随着术后时间的延长，外周血MMP-9水平逐渐降低。结论 ACS患者入院时外周血MMP-9水平升高， PCI术后即刻，外周血MMP-9水平均较入院时显著升高，随着术后时间的延长，外周血MMP-9水平逐渐降低。提示MMP-9可以作为诊断ACS的指标之一，术后检测有助于监测ACS患者术后病情的恢复情况。
Abstract:
AIM To observe continuous changes in serum levels of MMP-9 in patients with acute coronary syndromes (ACS) after PCI . METHODS Using enzymelinked immunosorbent assay (ELISA), we measuered the serum levels of MMP-9 in 39 patients with ACS. RESULTS The serum levels of MMP-9 in ACS group were significantly higher than those in control group and stable angina group ［（66±16) vs (24±11)μg/L, P<0.01；(66±16) vs (33±11)μg/L, P<0.01］. The serum levels of MMP-9 in stable angina group were significantly higher than those in control group［（33±11) vs (24±11)μg/L, P<0.01］. The serum levels of MMP-9 of ACS patients just after PCI were higher than those on admission (P<0.01). The serum levels of MMP-9 decreased slowly after PCI. CONCLUSION The serum levels of MMP-9 in ACS patients increase. Immediately after PCI, the levels of MMP-9 are higher than those on admission and they decrease slowly with the passage of time.

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备注/Memo

备注/Memo:
收稿日期：2006-06-05 通讯作者：李兰荪，教授，主任医师，主要从事冠心病的诊治研究Email:lilansun@sina.com 作者简介：殷忠，主治医师,硕士Email：ouandyin1219@163.com
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