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高血压病患者脉压与尿微量蛋白有关联(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第1期
页码:
89-90
栏目:
临床研究
出版日期:
2008-01-20

文章信息/Info

Title:
Relationship of pulse pressure and urinary micro protein in hypertensive patients
作者:
杨文 ; 李燕玲
海军总医院干二科,北京 100037
Author(s):
YANG Wen;  LI Yanling
Second Department of Geriatrics, Navy General Hospital, Beijing 100037, China
关键词:
高血压; 脉压; 尿微量蛋白
Keywords:
hypertension;  pulse pressure;  urinary micro protein
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的 探讨老年高血压病患者脉压与尿微量蛋白的关系。方法 对215例老年高血压病患者进行各脉压组之间尿微量白蛋白（ALB）的观察。结果 ALB在脉压为50～59 mmHg(1 mmHg=0.133 kPa)组和＜50 mmHg组、60～69 mmHg组和50～59 mmHg组、≥70 mmHg组和60～69 mmHg组之间均具有显著性差异（P<0.01）。多因素线性回归分析发现尿素氮、血糖和脉压是ALB的相关因子（P<0.05、P<0.01）。结论 脉压升高的老年高血压病患者，ALB增加。
Abstract:
AIM To study the relationship of pulse pressure to urine microprotein. METHODS We observed the urinary micro albumin (ALB) in 215 cases of hypertensive patients of different pulse pressure groups. RESULTS The ALB was significantly different in different pulse pressure groups (P<0.01). The ALB was significantly different between 50-59 mmHg pulse pressure group and ＜50 mmHg group, between 60-69 mmHg pulse pressure group and 50-59 mmHg group, and between ≥70 mmHg pulse pressure group and 60-69 mmHg group (P<0.01). With linear regression analysis, blood urinary nitrogen, fasting plasma glucose and pulse pressure were identified as significant and independent risk factors of ALB (P<0.05, P<0.01). CONCLUSION The pulse pressure increase is positively related to the ALB in hypertensive patients.

参考文献/References

［1］ Yuyun MF, Khaw KT, Luben R, et al. Microalbuminuria independently predicts allcause and cardiovascular mortality in a British population: The European Prospective Investigation into Cancer in Norfolk (EPICNorfolk) population study ［J］. Int J Epidemiol, 2004, 33（1）:189-198.

［2］ Darne B, Gierd X, Safar M, et al. Pulsatile versus steady component of blood pressure: a cross-sectional analysis and a prospective analysis on cardiovascular mortality ［J］. Hypertension, 1998, 13(4):392-400.

［3］ 林金秀,吴可贵. 1999年世界卫生组织/国际高血压联盟关于高血压治疗指南［J］. 高血压杂志,1999,7(2):97-100.

［4］ Pedrinelli R, Dell′Omo G , Penno G, et al. Microalbuminuria and pulse pressure in hypertensive and atherosclerotic men ［J］. Hypertension, 2000,35(1 Pt 1):48-54.

［5］ Smith A, Karalliedde J, De Angelis L, et al. Aortic pulse wave velocity and albuminuria in patients with type 2 diabetes ［J］. J Am Soc Nephrol,2005, 16(4): 1069-1075.

［6］ 杨文,王浩,王琪,等.高血压病患者脉压差与颈动脉超声的关系 ［J］.心肺血管病杂志，2002,21(2)：98-100.

［7］ Viazzi F, Leoncini G, Parodi D, et al. Pulse pressure and subclinical cardiovascular damage in primary hypertension ［J］. Nephrol Dial Transplant,2002, 17(10): 1779-1785.

备注/Memo

备注/Memo:
收稿日期：2006-09-05. 作者简介：杨文, 副主任医师, 硕士 Email:yangwen666123@sohu.com
更新日期/Last Update: