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超敏C反应蛋白、脂蛋白(α)和脂联素集成检测诊断冠心病的价值(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第2期
页码:
210-212
栏目:
临床研究
出版日期:
2008-03-20

文章信息/Info

Title:
Value of integrated detection of serum highsensitivity Creactive protein, lipoprotein(α) and adiponectin in diagnosis of coronary heart disease
作者:
李健洪1; 刘映峰1; 缪绯1; 金维荣2; 何笑恬2
1.广州市南方医科大学珠江医院心血管内科，广东 广州 510280；2.上海生物芯片有限公司，上海 201203
Author(s):
LI Jianhong1;  LIU Yingfeng1;  MIU fei1;  JIN Weirong2;  HE Xiaotian2
1.Department of Cardiology, Affiliated Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong, China; 2.Shanghai Biochip CO., LTD, Shanghai 201203, China
关键词:
超敏C反应蛋白; 脂蛋白(α); 脂联素; 冠状动脉疾病; 悬浮芯片
Keywords:
highsensitivity Creactive protein;  lipoprotein(α);  adiponectin;  coronary disease
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨超敏C反应蛋白（hsCRP）、脂蛋白(α) ［Lp(α)］和脂联素联合检测对冠心病的诊断价值。方法 对161例疑诊冠心病的患者进行冠状动脉造影检查，根据造影结果分为冠心病组和非冠心病组，收集5 ml无抗凝全血标本，分离血清，利用悬浮芯片同时检测同一标本hsCRP、Lp(α)和脂联素3个指标。结果 冠心病组hsCRP、Lp(α)测定值均显著高于非冠心病组(P<0.01)，而冠心病组脂联素测定值显著低于非冠心病组(P<0.01)；3个指标集成检测进行平行试验分析时灵敏度(90%)显著高于单个标志物检测的灵敏度［hsCRP 65%、Lp(α)74%、脂联素58％，P<0.01］，进行系列试验分析时特异度(92％)显著高于单个标志物检测的特异度(hsCRP 85%、Lp(α)69%、脂联素75％，P<0.01)。结论 集成检测hsCRP、Lp(α)和脂联素能更准确诊断冠心病，有效的减少漏诊与误诊。
Abstract:
AIM To study the value of integrated detection of serum highsensitivity Creactive protein (hsCRP), lipoprotein(α) ［Lp(α)］ and adiponectin in diagnosis of coronary heart disease (CHD). METHODS One hundred and sixtyone suspected cases of CHD underwent coronary angiography and were classified into CHD group and nonCHD group. 5mL peripheral blood were drawn from all the subjects and the serum samples were separated. hsCRP, Lp(α) and adiponectin were evaluated and analyzed in both groups by suspension chip. RESULTS The concentration of hsCRP and Lp(α) was significantly higher in CHD patients than that in nonCHD subjects (P<0.01) and the concentration of adiponectin was significantly lower in CHD patients compared with that in nonCHD subjects (P<0.01). By parallel tests, the sensitivity of integrated detection all the three markers (0.90) was higher than that of single marker detection of either hsCRP (0.65) or Lp(α) (0.74) or adiponectin (0.58) (P<0.01). By serial tests, the specificity of integrated detection all the three markers (0.92) was higher than that of single marker detection of either hsCRP (0.85) or Lp(α) (0.69) or adiponectin (0.75) (P<0.01). CONCLUSION Integrated detection of three markers of hsCRP, Lp(α) and adiponectin is more accurate and reliable in the diagnosis of CHD．

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2007-10-24.基金项目：广东省科技计划项目(2007B03150810) 通讯作者：刘映峰，主任医师，教授，主要从事冠心病早期诊断研究Email: abnesaorn@yahoo.com.cn 作者简介：李健洪，硕士生Email: anson_1981@163.com
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